Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187347> ?p ?o ?g. }
Showing items 1 to 41 of
41
with 100 items per page.
- NCIT_C187347 IAO_0000115 "A half-life extended (HLE) human bispecific T-cell engager (BiTE) antibody targeting the CD3 antigen expressed on T-lymphocytes and the cell surface protein claudin 6 (CLDN6; CLDN-6), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, anti-CLDN6/CD3 BiTE antibody AMG 794 targets and binds to both CD3 expressed on T-cells and CLDN6 expressed on tumor cells. This activates and redirects cytotoxic T-lymphocytes (CTLs) to CLDN6-expressing tumor cells, produces cytokines and leads to enhanced CTL-mediated elimination of CLDN6-expressing tumor cells. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells." @default.
- NCIT_C187347 NCIT_A7 NCIT_C96024 @default.
- NCIT_C187347 NCIT_NHC0 "C187347" @default.
- NCIT_C187347 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187347 NCIT_P108 "Anti-CLDN6/CD3 BiTE Antibody AMG 794" @default.
- NCIT_C187347 NCIT_P208 "CL1792159" @default.
- NCIT_C187347 NCIT_P322 "GDC" @default.
- NCIT_C187347 NCIT_P399 "809523" @default.
- NCIT_C187347 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187347 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187347 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187347 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187347 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187347 normalizedInformationContent "100" @default.
- NCIT_C187347 referenceCount "1" @default.
- NCIT_C187347 hasExactSynonym "AMG 794" @default.
- NCIT_C187347 hasExactSynonym "AMG-794" @default.
- NCIT_C187347 hasExactSynonym "AMG794" @default.
- NCIT_C187347 hasExactSynonym "Anti-CLDN6/CD3 BiTE Antibody AMG 794" @default.
- NCIT_C187347 hasExactSynonym "CLDN6/CD3 Bispecific T-cell Engager AMG 794" @default.
- NCIT_C187347 hasExactSynonym "CLDN6xCD3 Bispecific T-cell Engager AMG 794" @default.
- NCIT_C187347 inSubset NCIT_C128784 @default.
- NCIT_C187347 inSubset NCIT_C157711 @default.
- NCIT_C187347 inSubset NCIT_C157712 @default.
- NCIT_C187347 inSubset NCIT_C176424 @default.
- NCIT_C187347 type Class @default.
- NCIT_C187347 isDefinedBy ncit.owl @default.
- NCIT_C187347 label "Anti-CLDN6/CD3 BiTE Antibody AMG 794" @default.
- NCIT_C187347 subClassOf NCIT_C112883 @default.
- NCIT_C187347 subClassOf NCIT_C129821 @default.
- NCIT_C187347 subClassOf NCIT_C129822 @default.
- NCIT_C187347 subClassOf NCIT_C1454 @default.
- NCIT_C187347 subClassOf NCIT_C187347 @default.
- NCIT_C187347 subClassOf NCIT_C1908 @default.
- NCIT_C187347 subClassOf NCIT_C1909 @default.
- NCIT_C187347 subClassOf NCIT_C201282 @default.
- NCIT_C187347 subClassOf NCIT_C20401 @default.
- NCIT_C187347 subClassOf NCIT_C274 @default.
- NCIT_C187347 subClassOf NCIT_C28227 @default.
- NCIT_C187347 subClassOf NCIT_C307 @default.
- NCIT_C187347 subClassOf NCIT_C308 @default.