Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187350> ?p ?o ?g. }
Showing items 1 to 35 of
35
with 100 items per page.
- NCIT_C187350 IAO_0000115 "An orally bioavailable, small molecule inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA; PI3K p110alpha) mutant(s), with potential antineoplastic activity. Upon oral administration, PI3K-alpha inhibitor BPI-21668 selectively targets, binds to and inhibits the activity of PIK3CA mutant(s), in the PI3K/Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA mutant-expressing tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K." @default.
- NCIT_C187350 NCIT_A7 NCIT_C30168 @default.
- NCIT_C187350 NCIT_NHC0 "C187350" @default.
- NCIT_C187350 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187350 NCIT_P108 "Mutant-selective PI3K-alpha Inhibitor BPI-21668" @default.
- NCIT_C187350 NCIT_P208 "CL1792158" @default.
- NCIT_C187350 NCIT_P322 "GDC" @default.
- NCIT_C187350 NCIT_P399 "809546" @default.
- NCIT_C187350 normalizedInformationContent "100" @default.
- NCIT_C187350 referenceCount "1" @default.
- NCIT_C187350 hasExactSynonym "BPI 21668" @default.
- NCIT_C187350 hasExactSynonym "BPI-21668" @default.
- NCIT_C187350 hasExactSynonym "BPI21668" @default.
- NCIT_C187350 hasExactSynonym "Mutant-selective PI3K-alpha Inhibitor BPI-21668" @default.
- NCIT_C187350 hasExactSynonym "PI3K-alpha Inhibitor BPI-21668" @default.
- NCIT_C187350 hasExactSynonym "PIK3CA Inhibitor BPI-21668" @default.
- NCIT_C187350 inSubset NCIT_C128784 @default.
- NCIT_C187350 inSubset NCIT_C157711 @default.
- NCIT_C187350 inSubset NCIT_C157712 @default.
- NCIT_C187350 inSubset NCIT_C176424 @default.
- NCIT_C187350 type Class @default.
- NCIT_C187350 isDefinedBy ncit.owl @default.
- NCIT_C187350 label "Mutant-selective PI3K-alpha Inhibitor BPI-21668" @default.
- NCIT_C187350 subClassOf NCIT_C129824 @default.
- NCIT_C187350 subClassOf NCIT_C129825 @default.
- NCIT_C187350 subClassOf NCIT_C1404 @default.
- NCIT_C187350 subClassOf NCIT_C163758 @default.
- NCIT_C187350 subClassOf NCIT_C1742 @default.
- NCIT_C187350 subClassOf NCIT_C187350 @default.
- NCIT_C187350 subClassOf NCIT_C1908 @default.
- NCIT_C187350 subClassOf NCIT_C1909 @default.
- NCIT_C187350 subClassOf NCIT_C2152 @default.
- NCIT_C187350 subClassOf NCIT_C2189 @default.
- NCIT_C187350 subClassOf NCIT_C274 @default.
- NCIT_C187350 subClassOf NCIT_C471 @default.