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- NCIT_C187375 IAO_0000115 "An orally bioavailable type II protein kinase inhibitor of multiple kinases, including c-Met (hepatocyte growth factor receptor; HGFR), FMS-like tyrosine kinase-3 (FLT3; CD135; fetal liver kinase-2; Flk2), tropomyosin-related-kinase (tyrosine receptor kinase; TRK), and cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and immunomodulating activities. Upon oral administration, c-Met/FLT3/TRK/CDK8/19 inhibitor TSN084 targets, binds to and inhibits the activity of various kinases, such as c-Met, FLT3, TRK and CDK8/19, and prevents activation of oncogenic signaling pathways mediated by these kinases, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of susceptible tumor cells that overexpress these kinases. These kinases are overexpressed or mutated in certain cancer cell types and play key roles in tumor cell proliferation, survival, invasion, treatment resistance and immune evasion." @default.
- NCIT_C187375 NCIT_A7 NCIT_C18186 @default.
- NCIT_C187375 NCIT_A7 NCIT_C26202 @default.
- NCIT_C187375 NCIT_A7 NCIT_C28558 @default.
- NCIT_C187375 NCIT_A7 NCIT_C33983 @default.
- NCIT_C187375 NCIT_A7 NCIT_C33984 @default.
- NCIT_C187375 NCIT_A7 NCIT_C95299 @default.
- NCIT_C187375 NCIT_NHC0 "C187375" @default.
- NCIT_C187375 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187375 NCIT_P107 "c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084" @default.
- NCIT_C187375 NCIT_P108 "c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084" @default.
- NCIT_C187375 NCIT_P208 "CL1792200" @default.
- NCIT_C187375 NCIT_P322 "CTRP" @default.
- NCIT_C187375 NCIT_P322 "GDC" @default.
- NCIT_C187375 NCIT_P399 "810802" @default.
- NCIT_C187375 normalizedInformationContent "100" @default.
- NCIT_C187375 referenceCount "1" @default.
- NCIT_C187375 hasExactSynonym "Multiple Kinase Inhibitor TSN084" @default.
- NCIT_C187375 hasExactSynonym "Protein Kinase Inhibitor TSN084" @default.
- NCIT_C187375 hasExactSynonym "TSN 084" @default.
- NCIT_C187375 hasExactSynonym "TSN-084" @default.
- NCIT_C187375 hasExactSynonym "TSN084" @default.
- NCIT_C187375 hasExactSynonym "c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084" @default.
- NCIT_C187375 inSubset NCIT_C116977 @default.
- NCIT_C187375 inSubset NCIT_C116978 @default.
- NCIT_C187375 inSubset NCIT_C128784 @default.
- NCIT_C187375 inSubset NCIT_C157711 @default.
- NCIT_C187375 inSubset NCIT_C157712 @default.
- NCIT_C187375 inSubset NCIT_C176424 @default.
- NCIT_C187375 type Class @default.
- NCIT_C187375 isDefinedBy ncit.owl @default.
- NCIT_C187375 label "c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084" @default.
- NCIT_C187375 subClassOf NCIT_C124800 @default.
- NCIT_C187375 subClassOf NCIT_C129824 @default.
- NCIT_C187375 subClassOf NCIT_C129825 @default.
- NCIT_C187375 subClassOf NCIT_C1404 @default.
- NCIT_C187375 subClassOf NCIT_C143099 @default.
- NCIT_C187375 subClassOf NCIT_C155765 @default.
- NCIT_C187375 subClassOf NCIT_C163758 @default.
- NCIT_C187375 subClassOf NCIT_C163790 @default.
- NCIT_C187375 subClassOf NCIT_C164000 @default.
- NCIT_C187375 subClassOf NCIT_C187375 @default.
- NCIT_C187375 subClassOf NCIT_C1908 @default.
- NCIT_C187375 subClassOf NCIT_C1909 @default.
- NCIT_C187375 subClassOf NCIT_C1967 @default.
- NCIT_C187375 subClassOf NCIT_C2185 @default.
- NCIT_C187375 subClassOf NCIT_C2189 @default.
- NCIT_C187375 subClassOf NCIT_C274 @default.
- NCIT_C187375 subClassOf NCIT_C471 @default.
- NCIT_C187375 subClassOf NCIT_C61074 @default.