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- NCIT_C187654 IAO_0000115 "An Fc-bearing, bispecific antibody-like protein directed against the tumor-associated antigen (TAA) CD123 and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD123/anti-CD3 bispecific DART molecule MGD024 simultaneously binds to both CD123-expressing cancer cells and CD3-expressing T-cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha chain, is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells. The Fc domain prolongs the half-life of the agent, and a reduced affinity of CD3-binding results in less cytokine release." @default.
- NCIT_C187654 NCIT_A7 NCIT_C39275 @default.
- NCIT_C187654 NCIT_NHC0 "C187654" @default.
- NCIT_C187654 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187654 NCIT_P108 "Anti-CD123/Anti-CD3 Bispecific DART Molecule MGD024" @default.
- NCIT_C187654 NCIT_P208 "CL1792340" @default.
- NCIT_C187654 NCIT_P322 "GDC" @default.
- NCIT_C187654 NCIT_P399 "809717" @default.
- NCIT_C187654 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187654 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187654 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187654 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187654 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187654 normalizedInformationContent "100" @default.
- NCIT_C187654 referenceCount "1" @default.
- NCIT_C187654 hasExactSynonym "Anti-CD123/Anti-CD3 Bispecific Antibody MGD024" @default.
- NCIT_C187654 hasExactSynonym "Anti-CD123/Anti-CD3 Bispecific DART Molecule MGD024" @default.
- NCIT_C187654 hasExactSynonym "Anti-CD123/CD3 Bispecific DART Molecule MGD024" @default.
- NCIT_C187654 hasExactSynonym "CD123 x CD3 Bispecific DART Molecule MGD024" @default.
- NCIT_C187654 hasExactSynonym "Dual-Affinity Re-Targeting Protein MGD024" @default.
- NCIT_C187654 hasExactSynonym "MGD 024" @default.
- NCIT_C187654 hasExactSynonym "MGD-024" @default.
- NCIT_C187654 hasExactSynonym "MGD024" @default.
- NCIT_C187654 inSubset NCIT_C128784 @default.
- NCIT_C187654 inSubset NCIT_C157711 @default.
- NCIT_C187654 inSubset NCIT_C157712 @default.
- NCIT_C187654 inSubset NCIT_C176424 @default.
- NCIT_C187654 type Class @default.
- NCIT_C187654 isDefinedBy ncit.owl @default.
- NCIT_C187654 label "Anti-CD123/Anti-CD3 Bispecific DART Molecule MGD024" @default.
- NCIT_C187654 subClassOf NCIT_C112883 @default.
- NCIT_C187654 subClassOf NCIT_C129821 @default.
- NCIT_C187654 subClassOf NCIT_C129822 @default.
- NCIT_C187654 subClassOf NCIT_C1454 @default.
- NCIT_C187654 subClassOf NCIT_C187654 @default.
- NCIT_C187654 subClassOf NCIT_C1908 @default.
- NCIT_C187654 subClassOf NCIT_C1909 @default.
- NCIT_C187654 subClassOf NCIT_C201282 @default.
- NCIT_C187654 subClassOf NCIT_C201511 @default.
- NCIT_C187654 subClassOf NCIT_C20401 @default.
- NCIT_C187654 subClassOf NCIT_C274 @default.
- NCIT_C187654 subClassOf NCIT_C28227 @default.
- NCIT_C187654 subClassOf NCIT_C307 @default.
- NCIT_C187654 subClassOf NCIT_C308 @default.