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- NCIT_C187655 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed against the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19), that is site-specifically conjugated with a tumor-cleavable beta-glucuronide linker to a tumor-cleavable prodrug of pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of anti-CD19 ADC IKS03 targets and binds to CD19 expressed on tumor cells. Upon binding and internalization, both the linker and prodrug are selectively cleaved by lysosomal b-glucuronidase overexpressed in tumor cells. Free PBD is released and forms highly cytotoxic DNA interstrand cross-links, thereby blocking cell division and killing CD19-expressing cancer cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies." @default.
- NCIT_C187655 NCIT_A7 NCIT_C38894 @default.
- NCIT_C187655 NCIT_NHC0 "C187655" @default.
- NCIT_C187655 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187655 NCIT_P108 "Anti-CD19 Antibody-drug Conjugate IKS03" @default.
- NCIT_C187655 NCIT_P208 "CL1792337" @default.
- NCIT_C187655 NCIT_P322 "GDC" @default.
- NCIT_C187655 NCIT_P399 "809719" @default.
- NCIT_C187655 normalizedInformationContent "100" @default.
- NCIT_C187655 referenceCount "1" @default.
- NCIT_C187655 hasExactSynonym "Anti-CD19 ADC IKS03" @default.
- NCIT_C187655 hasExactSynonym "Anti-CD19 Antibody-drug Conjugate IKS03" @default.
- NCIT_C187655 hasExactSynonym "Anti-CD19/PBD ADC IKS03" @default.
- NCIT_C187655 hasExactSynonym "IKS 03" @default.
- NCIT_C187655 hasExactSynonym "IKS-03" @default.
- NCIT_C187655 hasExactSynonym "IKS03" @default.
- NCIT_C187655 hasExactSynonym "LCB 73" @default.
- NCIT_C187655 hasExactSynonym "LCB-73" @default.
- NCIT_C187655 hasExactSynonym "LCB73" @default.
- NCIT_C187655 inSubset NCIT_C128784 @default.
- NCIT_C187655 inSubset NCIT_C157711 @default.
- NCIT_C187655 inSubset NCIT_C157712 @default.
- NCIT_C187655 inSubset NCIT_C176424 @default.
- NCIT_C187655 type Class @default.
- NCIT_C187655 isDefinedBy ncit.owl @default.
- NCIT_C187655 label "Anti-CD19 Antibody-drug Conjugate IKS03" @default.
- NCIT_C187655 subClassOf NCIT_C129821 @default.
- NCIT_C187655 subClassOf NCIT_C129823 @default.
- NCIT_C187655 subClassOf NCIT_C1512 @default.
- NCIT_C187655 subClassOf NCIT_C163758 @default.
- NCIT_C187655 subClassOf NCIT_C187655 @default.
- NCIT_C187655 subClassOf NCIT_C1908 @default.
- NCIT_C187655 subClassOf NCIT_C1909 @default.
- NCIT_C187655 subClassOf NCIT_C198634 @default.
- NCIT_C187655 subClassOf NCIT_C198859 @default.
- NCIT_C187655 subClassOf NCIT_C274 @default.
- NCIT_C187655 subClassOf NCIT_C307 @default.
- NCIT_C187655 subClassOf NCIT_C308 @default.