Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187656> ?p ?o ?g. }
Showing items 1 to 30 of
30
with 100 items per page.
- NCIT_C187656 IAO_0000115 "A sustained-release (SR) formulation of the synthetic octapeptide and somatostatin analog octreotide, with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities. Upon intramuscular administration of octreotide SR formulation Debio 4126, octreotide binds to and activates somatostatin receptors (SSTRs), including subtypes 2 and 5, which leads to an inhibition in the secretion of human growth hormone (hGH) in the pituitary gland and results in decreased production of insulin-like growth factor (IGF-1). This may inhibit IGF-1-mediated cell signaling pathways, and lead to apoptosis. Octreotide may also block key survival pathways such as the phosphatidylinositol 3-kinase (PI3K) and the mitogen-activated protein kinase (MAPK) signaling pathways. In addition, octreotide may inhibit tumor angiogenesis. Altogether, this may result in tumor cell death and inhibition of tumor cell proliferation and angiogenesis. SSTRs are overexpressed by some neuroendocrine and non-neuroendocrine tumor cells, and GH is over-produced in the pituitary gland in acromegaly." @default.
- NCIT_C187656 NCIT_A7 NCIT_C17922 @default.
- NCIT_C187656 NCIT_A7 NCIT_C17927 @default.
- NCIT_C187656 NCIT_NHC0 "C187656" @default.
- NCIT_C187656 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187656 NCIT_P108 "Octreotide Sustained-release Formulation Debio 4126" @default.
- NCIT_C187656 NCIT_P208 "CL1792338" @default.
- NCIT_C187656 NCIT_P322 "GDC" @default.
- NCIT_C187656 NCIT_P399 "809720" @default.
- NCIT_C187656 normalizedInformationContent "100" @default.
- NCIT_C187656 referenceCount "1" @default.
- NCIT_C187656 hasExactSynonym "Debio 4126" @default.
- NCIT_C187656 hasExactSynonym "Debio-4126" @default.
- NCIT_C187656 hasExactSynonym "Debio4126" @default.
- NCIT_C187656 hasExactSynonym "Long-acting Octreotide Formulation Debio 4126" @default.
- NCIT_C187656 hasExactSynonym "Octreotide SR Formulation Debio 4126" @default.
- NCIT_C187656 hasExactSynonym "Octreotide Sustained-release Formulation Debio 4126" @default.
- NCIT_C187656 inSubset NCIT_C128784 @default.
- NCIT_C187656 inSubset NCIT_C157711 @default.
- NCIT_C187656 inSubset NCIT_C157712 @default.
- NCIT_C187656 inSubset NCIT_C176424 @default.
- NCIT_C187656 type Class @default.
- NCIT_C187656 isDefinedBy ncit.owl @default.
- NCIT_C187656 label "Octreotide Sustained-release Formulation Debio 4126" @default.
- NCIT_C187656 subClassOf NCIT_C147908 @default.
- NCIT_C187656 subClassOf NCIT_C187656 @default.
- NCIT_C187656 subClassOf NCIT_C1908 @default.
- NCIT_C187656 subClassOf NCIT_C1909 @default.
- NCIT_C187656 subClassOf NCIT_C548 @default.
- NCIT_C187656 subClassOf NCIT_C62799 @default.