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- NCIT_C187658 IAO_0000115 "A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CLDN18.2/anti-CD3 bispecific antibody ASP2138 simultaneously binds to both CLDN18.2-expressing tumor cells and CD3-expressing T-cells, thereby crosslinking CLDN18.2-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C187658 NCIT_A7 NCIT_C150412 @default.
- NCIT_C187658 NCIT_NHC0 "C187658" @default.
- NCIT_C187658 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187658 NCIT_P107 "Anti-CLDN18.2/Anti-CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 NCIT_P108 "Anti-CLDN18.2/Anti-CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 NCIT_P208 "CL1792336" @default.
- NCIT_C187658 NCIT_P322 "CTRP" @default.
- NCIT_C187658 NCIT_P322 "GDC" @default.
- NCIT_C187658 NCIT_P399 "809745" @default.
- NCIT_C187658 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187658 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187658 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187658 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187658 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187658 normalizedInformationContent "100" @default.
- NCIT_C187658 referenceCount "1" @default.
- NCIT_C187658 hasExactSynonym "ASP 2138" @default.
- NCIT_C187658 hasExactSynonym "ASP-2138" @default.
- NCIT_C187658 hasExactSynonym "ASP2138" @default.
- NCIT_C187658 hasExactSynonym "Anti-CLDN18.2/Anti-CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 hasExactSynonym "Anti-Claudin18.2/Anti-CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 hasExactSynonym "Anti-Claudin18.2/CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 hasExactSynonym "Claudin18.2 x CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 inSubset NCIT_C116977 @default.
- NCIT_C187658 inSubset NCIT_C116978 @default.
- NCIT_C187658 inSubset NCIT_C128784 @default.
- NCIT_C187658 inSubset NCIT_C157711 @default.
- NCIT_C187658 inSubset NCIT_C157712 @default.
- NCIT_C187658 inSubset NCIT_C176424 @default.
- NCIT_C187658 type Class @default.
- NCIT_C187658 isDefinedBy ncit.owl @default.
- NCIT_C187658 label "Anti-CLDN18.2/Anti-CD3 Bispecific Antibody ASP2138" @default.
- NCIT_C187658 subClassOf NCIT_C112883 @default.
- NCIT_C187658 subClassOf NCIT_C129821 @default.
- NCIT_C187658 subClassOf NCIT_C129822 @default.
- NCIT_C187658 subClassOf NCIT_C1454 @default.
- NCIT_C187658 subClassOf NCIT_C163758 @default.
- NCIT_C187658 subClassOf NCIT_C179676 @default.
- NCIT_C187658 subClassOf NCIT_C187658 @default.
- NCIT_C187658 subClassOf NCIT_C1908 @default.
- NCIT_C187658 subClassOf NCIT_C1909 @default.
- NCIT_C187658 subClassOf NCIT_C200250 @default.
- NCIT_C187658 subClassOf NCIT_C201282 @default.
- NCIT_C187658 subClassOf NCIT_C20401 @default.
- NCIT_C187658 subClassOf NCIT_C274 @default.
- NCIT_C187658 subClassOf NCIT_C28227 @default.
- NCIT_C187658 subClassOf NCIT_C307 @default.
- NCIT_C187658 subClassOf NCIT_C308 @default.