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- NCIT_C187660 IAO_0000115 "An orally bioavailable small molecule inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor HS-10370 selectively targets, binds to and inhibits the activity of the KRAS G12C mutant, thereby inhibiting KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis." @default.
- NCIT_C187660 NCIT_A7 NCIT_C98365 @default.
- NCIT_C187660 NCIT_NHC0 "C187660" @default.
- NCIT_C187660 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187660 NCIT_P108 "KRAS G12C Inhibitor HS-10370" @default.
- NCIT_C187660 NCIT_P208 "CL1792334" @default.
- NCIT_C187660 NCIT_P322 "GDC" @default.
- NCIT_C187660 NCIT_P399 "809747" @default.
- NCIT_C187660 normalizedInformationContent "100" @default.
- NCIT_C187660 referenceCount "1" @default.
- NCIT_C187660 hasExactSynonym "HS 10370" @default.
- NCIT_C187660 hasExactSynonym "HS-10370" @default.
- NCIT_C187660 hasExactSynonym "HS10370" @default.
- NCIT_C187660 hasExactSynonym "KRAS G12C Inhibitor HS-10370" @default.
- NCIT_C187660 inSubset NCIT_C128784 @default.
- NCIT_C187660 inSubset NCIT_C157711 @default.
- NCIT_C187660 inSubset NCIT_C157712 @default.
- NCIT_C187660 inSubset NCIT_C176424 @default.
- NCIT_C187660 type Class @default.
- NCIT_C187660 isDefinedBy ncit.owl @default.
- NCIT_C187660 label "KRAS G12C Inhibitor HS-10370" @default.
- NCIT_C187660 subClassOf NCIT_C163758 @default.
- NCIT_C187660 subClassOf NCIT_C187660 @default.
- NCIT_C187660 subClassOf NCIT_C1902 @default.
- NCIT_C187660 subClassOf NCIT_C1908 @default.
- NCIT_C187660 subClassOf NCIT_C1909 @default.
- NCIT_C187660 subClassOf NCIT_C200729 @default.
- NCIT_C187660 subClassOf NCIT_C2189 @default.
- NCIT_C187660 subClassOf NCIT_C274 @default.