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- NCIT_C187686 IAO_0000115 "A preparation of autologous, interleukin-7 (IL-7)-expanded, human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous HER2-specific CD4+ T-cells are expanded ex vivo with IL-7. Upon reintroduction into the patient, the autologous IL-7-expanded HER2-specific CD4+ T-cells recognize and stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. IL-7 is a cytokine that promotes the proliferation and survival of T-cells." @default.
- NCIT_C187686 NCIT_A7 NCIT_C17319 @default.
- NCIT_C187686 NCIT_NHC0 "C187686" @default.
- NCIT_C187686 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187686 NCIT_P107 "Autologous IL-7-expanded HER2-specific CD4+ T-cells" @default.
- NCIT_C187686 NCIT_P108 "Autologous IL-7-expanded HER2-specific CD4+ T-cells" @default.
- NCIT_C187686 NCIT_P208 "CL1792367" @default.
- NCIT_C187686 NCIT_P322 "CTRP" @default.
- NCIT_C187686 NCIT_P399 "810511" @default.
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- NCIT_C187686 hasExactSynonym "Autologous IL-7 Expanded HER2-specific CD4+ T Cells" @default.
- NCIT_C187686 hasExactSynonym "Autologous IL-7-expanded HER2-specific CD4+ T-cells" @default.
- NCIT_C187686 hasExactSynonym "Autologous IL-7-expanded HER2-specific CD4+ T-lymphocytes" @default.
- NCIT_C187686 inSubset NCIT_C116977 @default.
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- NCIT_C187686 type Class @default.
- NCIT_C187686 isDefinedBy ncit.owl @default.
- NCIT_C187686 label "Autologous IL-7-expanded HER2-specific CD4+ T-cells" @default.
- NCIT_C187686 subClassOf NCIT_C129820 @default.
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