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- NCIT_C187688 IAO_0000115 "A preparation composed of ex-vivo expanded CXC chemokine receptor 2 (CXCR2) modified patient-derived activated CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7) chimeric antigen receptor (CAR) (8R-70CAR) T-cells, with potential immunostimulating and antineoplastic activities. Upon administration of the autologous CXCR2-modified CD70 CAR T-cells, the anti-CD70-CARs on the T-cell surfaces target and bind to the CD70 antigen on tumor cell surfaces. This induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against CD70-expressing tumor cells. CD70, a cytokine belonging to the tumor necrosis factor superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance. CXCR2, a transmembrane protein also known as interleukin (IL)-8 receptor B (IL-8RB), plays a key role in inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8 (IL-8), are expressed by tumor cells. CXCR2-modified CARs enhance intratumoral T-cell trafficking toward tumor cells and promotes persistence of T-cells. This may enhance the T-cell-mediated immune response against the CD70-expressing tumor cells." @default.
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- NCIT_C187688 NCIT_P108 "Autologous CXCR2-modified CD70 CAR T-cells" @default.
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- NCIT_C187688 hasExactSynonym "Autologous 8R-70CAR T-cells" @default.
- NCIT_C187688 hasExactSynonym "Autologous CXCR2-modified CD70 CAR T-cells" @default.
- NCIT_C187688 hasExactSynonym "Autologous IL-8RB-modified CD70-CAR T-cells" @default.
- NCIT_C187688 inSubset NCIT_C128784 @default.
- NCIT_C187688 inSubset NCIT_C176424 @default.
- NCIT_C187688 type Class @default.
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- NCIT_C187688 label "Autologous CXCR2-modified CD70 CAR T-cells" @default.
- NCIT_C187688 subClassOf NCIT_C129820 @default.
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