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- NCIT_C187690 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18) that is site-specifically conjugated, via a stable linker, to a cytotoxic DNA topoisomerase I (Top I) inhibitor, with potential antineoplastic activity. Upon administration of anti-CLDN18.2 ADC SKB315, the antibody moiety specifically targets and binds to CLDN18.2 expressed on tumor cells. Upon internalization and the release of the Top I inhibitor, the Top I inhibitor targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C187690 NCIT_A7 NCIT_C150412 @default.
- NCIT_C187690 NCIT_NHC0 "C187690" @default.
- NCIT_C187690 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187690 NCIT_P108 "Anti-Claudin 18.2 Antibody-drug Conjugate SKB315" @default.
- NCIT_C187690 NCIT_P208 "CL1792363" @default.
- NCIT_C187690 NCIT_P322 "GDC" @default.
- NCIT_C187690 NCIT_P399 "809641" @default.
- NCIT_C187690 normalizedInformationContent "100" @default.
- NCIT_C187690 referenceCount "1" @default.
- NCIT_C187690 hasExactSynonym "Anti-CLDN18.2 ADC SKB315" @default.
- NCIT_C187690 hasExactSynonym "Anti-Claudin 18.2 ADC SKB315" @default.
- NCIT_C187690 hasExactSynonym "Anti-Claudin 18.2 Antibody-drug Conjugate SKB315" @default.
- NCIT_C187690 hasExactSynonym "SKB 315" @default.
- NCIT_C187690 hasExactSynonym "SKB-315" @default.
- NCIT_C187690 hasExactSynonym "SKB315" @default.
- NCIT_C187690 inSubset NCIT_C128784 @default.
- NCIT_C187690 inSubset NCIT_C157711 @default.
- NCIT_C187690 inSubset NCIT_C157712 @default.
- NCIT_C187690 inSubset NCIT_C176424 @default.
- NCIT_C187690 type Class @default.
- NCIT_C187690 isDefinedBy ncit.owl @default.
- NCIT_C187690 label "Anti-Claudin 18.2 Antibody-drug Conjugate SKB315" @default.
- NCIT_C187690 subClassOf NCIT_C129821 @default.
- NCIT_C187690 subClassOf NCIT_C129823 @default.
- NCIT_C187690 subClassOf NCIT_C1512 @default.
- NCIT_C187690 subClassOf NCIT_C163758 @default.
- NCIT_C187690 subClassOf NCIT_C187690 @default.
- NCIT_C187690 subClassOf NCIT_C1908 @default.
- NCIT_C187690 subClassOf NCIT_C1909 @default.
- NCIT_C187690 subClassOf NCIT_C200250 @default.
- NCIT_C187690 subClassOf NCIT_C200251 @default.
- NCIT_C187690 subClassOf NCIT_C274 @default.
- NCIT_C187690 subClassOf NCIT_C307 @default.
- NCIT_C187690 subClassOf NCIT_C308 @default.