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- NCIT_C187693 IAO_0000115 "An orally bioavailable heterobifunctional protein degrader of bromodomain-containing protein 9 (BRD9; sarcoma antigen NY-SAR-29; rhabdomyosarcoma antigen MU-RMS-40.8), with potential antineoplastic activity. CFT8634 is comprised of an E3 ligase-binding moiety and a BRD9-binding moiety. Upon oral administration, BRD9 degrader CFT8634 targets and binds to BRD9 with its BRD9-binding moiety. Upon BRD9 binding, the E3 ligase-binding moiety binds to cereblon (CRBN), a component of the CRL4-CRBN E3 ubiquitin ligase complex, which directs proteins for destruction, resulting in the proteasome-mediated degradation of BRD9. This leads to an inhibition of the growth of tumor cells that rely on BRD9 for survival. BRD9, a component of one form of the Brg/Brahma-Associated Factor (BAF) complex, is needed for the survival of certain cancer cells due to mutations." @default.
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- NCIT_C187693 NCIT_NHC0 "C187693" @default.
- NCIT_C187693 NCIT_P106 "Organic Chemical" @default.
- NCIT_C187693 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187693 NCIT_P107 "BRD9 Degrader CFT8634" @default.
- NCIT_C187693 NCIT_P108 "BRD9 Degrader CFT8634" @default.
- NCIT_C187693 NCIT_P208 "CL1792374" @default.
- NCIT_C187693 NCIT_P322 "CTRP" @default.
- NCIT_C187693 NCIT_P322 "GDC" @default.
- NCIT_C187693 NCIT_P399 "809697" @default.
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- NCIT_C187693 hasExactSynonym "BRD9 Degrader CFT8634" @default.
- NCIT_C187693 hasExactSynonym "BRD9 Protein Degrader CFT8634" @default.
- NCIT_C187693 hasExactSynonym "BRD9-targeting Protein Degrader CFT8634" @default.
- NCIT_C187693 hasExactSynonym "BiDAC Degrader CFT8634" @default.
- NCIT_C187693 hasExactSynonym "Bifunctional Degradation Activating Compound CFT8634" @default.
- NCIT_C187693 hasExactSynonym "CFT 8634" @default.
- NCIT_C187693 hasExactSynonym "CFT-8634" @default.
- NCIT_C187693 hasExactSynonym "CFT8634" @default.
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- NCIT_C187693 type Class @default.
- NCIT_C187693 isDefinedBy ncit.owl @default.
- NCIT_C187693 label "BRD9 Degrader CFT8634" @default.
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