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- NCIT_C187694 IAO_0000115 "An orally bioavailable inhibitor of multiple receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, DDR1-2/VEGFR2-3/PDGFRalpha-beta inhibitor ICP-033 selectively targets, binds to and inhibits the activity of numerous RTKs including discoid domain receptor type 1 (DDR1) and 2 (DDR2), vascular endothelial growth factor receptors type 2 (VEGFR2) and 3 (VEGFR3) and platelet-derived growth factor receptor alpha (PDGFRa) and beta (PDGFRb). By inhibiting multiple RTKs located in endothelial cells, pericytes and stroma, ICP-033 may be able to inhibit angiogenesis and tumor cell invasion, normalize abnormal blood vessels, and reverse the immunosuppressive state of the tumor microenvironment (TME). This may halt tumor cell proliferation in susceptible tumor cells." @default.
- NCIT_C187694 NCIT_A7 NCIT_C17322 @default.
- NCIT_C187694 NCIT_A7 NCIT_C25855 @default.
- NCIT_C187694 NCIT_A7 NCIT_C26203 @default.
- NCIT_C187694 NCIT_A7 NCIT_C26211 @default.
- NCIT_C187694 NCIT_NHC0 "C187694" @default.
- NCIT_C187694 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187694 NCIT_P107 "DDR1-2/VEGFR2-3/PDGFRalpha-beta Inhibitor ICP-033" @default.
- NCIT_C187694 NCIT_P108 "DDR1-2/VEGFR2-3/PDGFRalpha-beta Inhibitor ICP-033" @default.
- NCIT_C187694 NCIT_P208 "CL1792375" @default.
- NCIT_C187694 NCIT_P322 "CTRP" @default.
- NCIT_C187694 NCIT_P322 "GDC" @default.
- NCIT_C187694 NCIT_P399 "809698" @default.
- NCIT_C187694 normalizedInformationContent "100" @default.
- NCIT_C187694 referenceCount "1" @default.
- NCIT_C187694 hasExactSynonym "DDR1-2/VEGFR2-3/PDGFRalpha-beta Inhibitor ICP-033" @default.
- NCIT_C187694 hasExactSynonym "ICP 033" @default.
- NCIT_C187694 hasExactSynonym "ICP-033" @default.
- NCIT_C187694 hasExactSynonym "ICP033" @default.
- NCIT_C187694 hasExactSynonym "RTK Inhibitor ICP-033" @default.
- NCIT_C187694 inSubset NCIT_C116977 @default.
- NCIT_C187694 inSubset NCIT_C116978 @default.
- NCIT_C187694 inSubset NCIT_C128784 @default.
- NCIT_C187694 inSubset NCIT_C157711 @default.
- NCIT_C187694 inSubset NCIT_C157712 @default.
- NCIT_C187694 inSubset NCIT_C176424 @default.
- NCIT_C187694 type Class @default.
- NCIT_C187694 isDefinedBy ncit.owl @default.
- NCIT_C187694 label "DDR1-2/VEGFR2-3/PDGFRalpha-beta Inhibitor ICP-033" @default.
- NCIT_C187694 subClassOf NCIT_C129824 @default.
- NCIT_C187694 subClassOf NCIT_C129825 @default.
- NCIT_C187694 subClassOf NCIT_C1404 @default.
- NCIT_C187694 subClassOf NCIT_C187694 @default.
- NCIT_C187694 subClassOf NCIT_C1908 @default.
- NCIT_C187694 subClassOf NCIT_C1909 @default.
- NCIT_C187694 subClassOf NCIT_C1967 @default.
- NCIT_C187694 subClassOf NCIT_C2189 @default.
- NCIT_C187694 subClassOf NCIT_C274 @default.
- NCIT_C187694 subClassOf NCIT_C471 @default.