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- NCIT_C187697 IAO_0000115 "A recombinant human bispecific antibody targeting both the tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR) and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-EGFR/anti-4-1BB bispecific antibody HLX35 simultaneously targets and binds to the extracellular domain of EGFR, which is expressed on a variety of tumor cells and 4-1BB, which is expressed on activated T-lymphocytes, natural killer (NK) cells and NK-T-cells. This crosslinks EGFR-expressing tumor cells and 4-1BB-expressing T-cells. The binding to EGFR inactivates EGFR and prevents EGFR-mediated signaling. Through 4-1BB binding, HLX35 acts as a conditional 4-1BB agonist, resulting in cytotoxic T-cell co-stimulation and enhances T-lymphocyte-mediated anti-tumor activity. It also activates memory T-cells, NK cells and dendritic cells (DCs) in the tumor microenvironment (TME). This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated lysis in EGFR-expressing tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. EGFR, belonging to the receptor tyrosine kinases family and upregulated or mutated in a variety of tumor cell types, plays a key role in tumor cell proliferation." @default.
- NCIT_C187697 NCIT_A7 NCIT_C17068 @default.
- NCIT_C187697 NCIT_NHC0 "C187697" @default.
- NCIT_C187697 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187697 NCIT_P108 "Anti-EGFR/Anti-4-1BB Bispecific Antibody HLX35" @default.
- NCIT_C187697 NCIT_P208 "CL1792373" @default.
- NCIT_C187697 NCIT_P322 "GDC" @default.
- NCIT_C187697 NCIT_P399 "809708" @default.
- NCIT_C187697 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187697 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187697 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187697 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187697 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187697 normalizedInformationContent "100" @default.
- NCIT_C187697 referenceCount "1" @default.
- NCIT_C187697 hasExactSynonym "Anti-EGFR/4-1BB Bispecific Antibody HLX35" @default.
- NCIT_C187697 hasExactSynonym "Anti-EGFR/Anti-4-1BB Bispecific Antibody HLX35" @default.
- NCIT_C187697 hasExactSynonym "BNA 035" @default.
- NCIT_C187697 hasExactSynonym "BNA-035" @default.
- NCIT_C187697 hasExactSynonym "BNA035" @default.
- NCIT_C187697 hasExactSynonym "EGFR x 4-1BB Bispecific Antibody HLX35" @default.
- NCIT_C187697 hasExactSynonym "HLX 35" @default.
- NCIT_C187697 hasExactSynonym "HLX-35" @default.
- NCIT_C187697 hasExactSynonym "HLX35" @default.
- NCIT_C187697 inSubset NCIT_C128784 @default.
- NCIT_C187697 inSubset NCIT_C157711 @default.
- NCIT_C187697 inSubset NCIT_C157712 @default.
- NCIT_C187697 inSubset NCIT_C176424 @default.
- NCIT_C187697 type Class @default.
- NCIT_C187697 isDefinedBy ncit.owl @default.
- NCIT_C187697 label "Anti-EGFR/Anti-4-1BB Bispecific Antibody HLX35" @default.
- NCIT_C187697 subClassOf NCIT_C129821 @default.
- NCIT_C187697 subClassOf NCIT_C129822 @default.
- NCIT_C187697 subClassOf NCIT_C141144 @default.
- NCIT_C187697 subClassOf NCIT_C143250 @default.
- NCIT_C187697 subClassOf NCIT_C1454 @default.
- NCIT_C187697 subClassOf NCIT_C187697 @default.
- NCIT_C187697 subClassOf NCIT_C1908 @default.
- NCIT_C187697 subClassOf NCIT_C1909 @default.
- NCIT_C187697 subClassOf NCIT_C20401 @default.
- NCIT_C187697 subClassOf NCIT_C274 @default.
- NCIT_C187697 subClassOf NCIT_C28227 @default.
- NCIT_C187697 subClassOf NCIT_C307 @default.
- NCIT_C187697 subClassOf NCIT_C308 @default.