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- NCIT_C1877 IAO_0000115 "A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins." @default.
- NCIT_C1877 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1877 NCIT_A7 NCIT_C171629 @default.
- NCIT_C1877 NCIT_NHC0 "C1877" @default.
- NCIT_C1877 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1877 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1877 NCIT_P107 "Cositecan" @default.
- NCIT_C1877 NCIT_P108 "Cositecan" @default.
- NCIT_C1877 NCIT_P175 "710270" @default.
- NCIT_C1877 NCIT_P207 "C0935985" @default.
- NCIT_C1877 NCIT_P210 "203923-89-1" @default.
- NCIT_C1877 NCIT_P319 "24R60NVC41" @default.
- NCIT_C1877 NCIT_P322 "CTRP" @default.
- NCIT_C1877 NCIT_P322 "FDA" @default.
- NCIT_C1877 NCIT_P322 "GDC" @default.
- NCIT_C1877 NCIT_P325 "A drug being studied in the treatment of cancer. It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin." @default.
- NCIT_C1877 NCIT_P329 "38211" @default.
- NCIT_C1877 NCIT_P330 "38211" @default.
- NCIT_C1877 NCIT_P350 "C25H28N2O4Si" @default.
- NCIT_C1877 NCIT_P366 "Karenitecin" @default.
- NCIT_C1877 NCIT_P375 "Cositecan" @default.
- NCIT_C1877 NCIT_P399 "38211" @default.
- NCIT_C1877 normalizedInformationContent "100" @default.
- NCIT_C1877 referenceCount "1" @default.
- NCIT_C1877 hasExactSynonym "(4S)-4-Ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione" @default.
- NCIT_C1877 hasExactSynonym "BNP1350" @default.
- NCIT_C1877 hasExactSynonym "COSITECAN" @default.
- NCIT_C1877 hasExactSynonym "Cositecan" @default.
- NCIT_C1877 hasExactSynonym "DB 172" @default.
- NCIT_C1877 hasExactSynonym "Karenitecin" @default.
- NCIT_C1877 hasExactSynonym "karenitecin" @default.
- NCIT_C1877 inSubset NCIT_C116977 @default.
- NCIT_C1877 inSubset NCIT_C116978 @default.
- NCIT_C1877 inSubset NCIT_C128784 @default.
- NCIT_C1877 inSubset NCIT_C157711 @default.
- NCIT_C1877 inSubset NCIT_C157712 @default.
- NCIT_C1877 inSubset NCIT_C176424 @default.
- NCIT_C1877 inSubset NCIT_C177537 @default.
- NCIT_C1877 inSubset NCIT_C63923 @default.
- NCIT_C1877 type Class @default.
- NCIT_C1877 isDefinedBy ncit.owl @default.
- NCIT_C1877 label "Cositecan" @default.
- NCIT_C1877 subClassOf NCIT_C129824 @default.
- NCIT_C1877 subClassOf NCIT_C129825 @default.
- NCIT_C1877 subClassOf NCIT_C1748 @default.
- NCIT_C1877 subClassOf NCIT_C1877 @default.
- NCIT_C1877 subClassOf NCIT_C1904 @default.
- NCIT_C1877 subClassOf NCIT_C1908 @default.
- NCIT_C1877 subClassOf NCIT_C1909 @default.
- NCIT_C1877 subClassOf NCIT_C2189 @default.
- NCIT_C1877 subClassOf NCIT_C274 @default.
- NCIT_C1877 subClassOf NCIT_C2843 @default.
- NCIT_C1877 subClassOf NCIT_C471 @default.