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- NCIT_C188045 IAO_0000115 "An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity. Upon administration, CDK2 inhibitor BLU-222 selectively targets, binds to and inhibits the activity of CDK2. This may lead to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDK2, a serine/threonine kinase that plays an important role in the regulation of cell cycle progression and cellular proliferation, is overexpressed in certain tumor cells." @default.
- NCIT_C188045 NCIT_A7 NCIT_C25842 @default.
- NCIT_C188045 NCIT_NHC0 "C188045" @default.
- NCIT_C188045 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188045 NCIT_P107 "CDK2 Inhibitor BLU-222" @default.
- NCIT_C188045 NCIT_P108 "CDK2 Inhibitor BLU-222" @default.
- NCIT_C188045 NCIT_P208 "CL1792897" @default.
- NCIT_C188045 NCIT_P322 "CTRP" @default.
- NCIT_C188045 NCIT_P322 "GDC" @default.
- NCIT_C188045 NCIT_P399 "810512" @default.
- NCIT_C188045 normalizedInformationContent "100" @default.
- NCIT_C188045 referenceCount "1" @default.
- NCIT_C188045 hasExactSynonym "BLU 222" @default.
- NCIT_C188045 hasExactSynonym "BLU-222" @default.
- NCIT_C188045 hasExactSynonym "BLU222" @default.
- NCIT_C188045 hasExactSynonym "CDK2 Inhibitor BLU-222" @default.
- NCIT_C188045 inSubset NCIT_C116977 @default.
- NCIT_C188045 inSubset NCIT_C116978 @default.
- NCIT_C188045 inSubset NCIT_C128784 @default.
- NCIT_C188045 inSubset NCIT_C157711 @default.
- NCIT_C188045 inSubset NCIT_C157712 @default.
- NCIT_C188045 inSubset NCIT_C176424 @default.
- NCIT_C188045 type Class @default.
- NCIT_C188045 isDefinedBy ncit.owl @default.
- NCIT_C188045 label "CDK2 Inhibitor BLU-222" @default.
- NCIT_C188045 subClassOf NCIT_C129824 @default.
- NCIT_C188045 subClassOf NCIT_C129825 @default.
- NCIT_C188045 subClassOf NCIT_C1404 @default.
- NCIT_C188045 subClassOf NCIT_C163758 @default.
- NCIT_C188045 subClassOf NCIT_C188045 @default.
- NCIT_C188045 subClassOf NCIT_C1908 @default.
- NCIT_C188045 subClassOf NCIT_C1909 @default.
- NCIT_C188045 subClassOf NCIT_C200052 @default.
- NCIT_C188045 subClassOf NCIT_C2185 @default.
- NCIT_C188045 subClassOf NCIT_C2189 @default.
- NCIT_C188045 subClassOf NCIT_C274 @default.
- NCIT_C188045 subClassOf NCIT_C471 @default.
- NCIT_C188045 subClassOf NCIT_C61074 @default.