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- NCIT_C188048 IAO_0000115 "An orally bioavailable inhibitor of the active, guanosine triphosphate (GTP)-bound form of both wild type and mutant variants of the RAS isoforms, including HRAS, NRAS and KRAS, with potential antineoplastic activity. Upon oral administration, RAS inhibitor RMC-6236 binds to an intracellular chaperone protein, cyclophilin A (CypA). The resulting inhibitory binary complex binds to active, GTP-bound RAS to form a tri-complex. This tri-complex inhibits RAS-dependent signaling and inhibits the proliferation of tumor cells in which RAS is overexpressed and/or mutated. RAS plays an important role in cell signaling, division and differentiation. Mutations of RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis." @default.
- NCIT_C188048 NCIT_A7 NCIT_C17061 @default.
- NCIT_C188048 NCIT_NHC0 "C188048" @default.
- NCIT_C188048 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188048 NCIT_P107 "RAS Inhibitor RMC-6236" @default.
- NCIT_C188048 NCIT_P108 "RAS Inhibitor RMC-6236" @default.
- NCIT_C188048 NCIT_P208 "CL1792828" @default.
- NCIT_C188048 NCIT_P322 "CTRP" @default.
- NCIT_C188048 NCIT_P322 "GDC" @default.
- NCIT_C188048 NCIT_P399 "809852" @default.
- NCIT_C188048 normalizedInformationContent "100" @default.
- NCIT_C188048 referenceCount "1" @default.
- NCIT_C188048 hasExactSynonym "RAS Inhibitor RMC-6236" @default.
- NCIT_C188048 hasExactSynonym "RASMUTLI(ON) Inhibitor RMC-6236" @default.
- NCIT_C188048 hasExactSynonym "RMC 6236" @default.
- NCIT_C188048 hasExactSynonym "RMC-6236" @default.
- NCIT_C188048 hasExactSynonym "RMC6236" @default.
- NCIT_C188048 hasExactSynonym "Ras-selective Tri-complex Inhibitor RMC-6236" @default.
- NCIT_C188048 inSubset NCIT_C116977 @default.
- NCIT_C188048 inSubset NCIT_C116978 @default.
- NCIT_C188048 inSubset NCIT_C128784 @default.
- NCIT_C188048 inSubset NCIT_C157711 @default.
- NCIT_C188048 inSubset NCIT_C157712 @default.
- NCIT_C188048 inSubset NCIT_C176424 @default.
- NCIT_C188048 type Class @default.
- NCIT_C188048 isDefinedBy ncit.owl @default.
- NCIT_C188048 label "RAS Inhibitor RMC-6236" @default.
- NCIT_C188048 subClassOf NCIT_C163758 @default.
- NCIT_C188048 subClassOf NCIT_C188048 @default.
- NCIT_C188048 subClassOf NCIT_C1902 @default.
- NCIT_C188048 subClassOf NCIT_C1908 @default.
- NCIT_C188048 subClassOf NCIT_C1909 @default.
- NCIT_C188048 subClassOf NCIT_C200729 @default.
- NCIT_C188048 subClassOf NCIT_C2189 @default.
- NCIT_C188048 subClassOf NCIT_C274 @default.