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- NCIT_C188052 IAO_0000115 "An orally bioavailable mimetic of the natural second mitochondrial-derived activator of caspases (Smac), with potential apoptotic-inducing, chemo-radio-sensitizing and antineoplastic activities. Upon oral administration, Smac mimetic BGB-24714 targets and binds to the Smac binding groove on inhibitor of apoptosis proteins (IAPs), including the direct caspase inhibitor X chromosome-linked IAP (XIAP), and the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2). This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress both intrinsic and extrinsic apoptosis by binding to and inhibiting active caspases via their baculoviral lAP repeat (BIR) domains. They contribute to chemo-radio-resistance of cancer cells to certain cytotoxic agents and radiation, promote tumor cell survival and are associated with poor prognosis in certain types of cancer. Smac, a pro-apoptotic mitochondrial protein, is an endogenous inhibitor of the IAPs family of cellular proteins." @default.
- NCIT_C188052 NCIT_NHC0 "C188052" @default.
- NCIT_C188052 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188052 NCIT_P107 "Smac Mimetic BGB-24714" @default.
- NCIT_C188052 NCIT_P108 "Smac Mimetic BGB-24714" @default.
- NCIT_C188052 NCIT_P208 "CL1792826" @default.
- NCIT_C188052 NCIT_P322 "CTRP" @default.
- NCIT_C188052 NCIT_P322 "GDC" @default.
- NCIT_C188052 NCIT_P399 "809853" @default.
- NCIT_C188052 normalizedInformationContent "100" @default.
- NCIT_C188052 referenceCount "1" @default.
- NCIT_C188052 hasExactSynonym "BGB 24714" @default.
- NCIT_C188052 hasExactSynonym "BGB-24714" @default.
- NCIT_C188052 hasExactSynonym "BGB24714" @default.
- NCIT_C188052 hasExactSynonym "Second Mitochondrial-derived Activator of Caspases Mimetic BGB-24714" @default.
- NCIT_C188052 hasExactSynonym "Smac Mimetic BGB-24714" @default.
- NCIT_C188052 inSubset NCIT_C116977 @default.
- NCIT_C188052 inSubset NCIT_C116978 @default.
- NCIT_C188052 inSubset NCIT_C128784 @default.
- NCIT_C188052 inSubset NCIT_C157711 @default.
- NCIT_C188052 inSubset NCIT_C157712 @default.
- NCIT_C188052 inSubset NCIT_C176424 @default.
- NCIT_C188052 type Class @default.
- NCIT_C188052 isDefinedBy ncit.owl @default.
- NCIT_C188052 label "Smac Mimetic BGB-24714" @default.
- NCIT_C188052 subClassOf NCIT_C129839 @default.
- NCIT_C188052 subClassOf NCIT_C188052 @default.
- NCIT_C188052 subClassOf NCIT_C1908 @default.
- NCIT_C188052 subClassOf NCIT_C1909 @default.
- NCIT_C188052 subClassOf NCIT_C274 @default.