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- NCIT_C188054 IAO_0000115 "An orally bioavailable, brain-penetrant, selective small molecule inhibitor of the receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral administration, ALK inhibitor NVL-655 specifically targets, binds to and inhibits ALK fusion proteins and activating mutations, including the acquired resistance mutations solvent front mutation (SFM) G1202R and the compound mutations G1202R/L1196M and G1202R/G1269A. The inhibition of ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types. NVL-655 is able to penetrate the blood-brain-barrier (BBB) and may therefore exert its activity against EGFR-driven central nervous system (CNS) primary tumors and CNS metastases." @default.
- NCIT_C188054 NCIT_A7 NCIT_C27032 @default.
- NCIT_C188054 NCIT_NHC0 "C188054" @default.
- NCIT_C188054 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188054 NCIT_P108 "ALK Inhibitor NVL-655" @default.
- NCIT_C188054 NCIT_P208 "CL1792824" @default.
- NCIT_C188054 NCIT_P322 "GDC" @default.
- NCIT_C188054 NCIT_P399 "809856" @default.
- NCIT_C188054 normalizedInformationContent "100" @default.
- NCIT_C188054 referenceCount "1" @default.
- NCIT_C188054 hasExactSynonym "ALK Inhibitor NUV-655" @default.
- NCIT_C188054 hasExactSynonym "ALK Inhibitor NVL-655" @default.
- NCIT_C188054 hasExactSynonym "NUV 655" @default.
- NCIT_C188054 hasExactSynonym "NUV-655" @default.
- NCIT_C188054 hasExactSynonym "NUV655" @default.
- NCIT_C188054 hasExactSynonym "NVL 655" @default.
- NCIT_C188054 hasExactSynonym "NVL-655" @default.
- NCIT_C188054 hasExactSynonym "NVL655" @default.
- NCIT_C188054 inSubset NCIT_C128784 @default.
- NCIT_C188054 inSubset NCIT_C157711 @default.
- NCIT_C188054 inSubset NCIT_C157712 @default.
- NCIT_C188054 inSubset NCIT_C176424 @default.
- NCIT_C188054 type Class @default.
- NCIT_C188054 isDefinedBy ncit.owl @default.
- NCIT_C188054 label "ALK Inhibitor NVL-655" @default.
- NCIT_C188054 subClassOf NCIT_C129824 @default.
- NCIT_C188054 subClassOf NCIT_C129825 @default.
- NCIT_C188054 subClassOf NCIT_C1404 @default.
- NCIT_C188054 subClassOf NCIT_C141136 @default.
- NCIT_C188054 subClassOf NCIT_C163758 @default.
- NCIT_C188054 subClassOf NCIT_C188054 @default.
- NCIT_C188054 subClassOf NCIT_C1908 @default.
- NCIT_C188054 subClassOf NCIT_C1909 @default.
- NCIT_C188054 subClassOf NCIT_C1967 @default.
- NCIT_C188054 subClassOf NCIT_C2189 @default.
- NCIT_C188054 subClassOf NCIT_C274 @default.
- NCIT_C188054 subClassOf NCIT_C471 @default.