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- NCIT_C188056 IAO_0000115 "A preparation of donor-derived, haploidentical, cytokine-activated natural killer (NK) cells enriched with mononuclear cells from haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that may potentially be used for immune reconstitution purposes. Upon administration, the donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells may enhance immune reconstitution. The depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders." @default.
- NCIT_C188056 NCIT_NHC0 "C188056" @default.
- NCIT_C188056 NCIT_P106 "Cell" @default.
- NCIT_C188056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188056 NCIT_P108 "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells" @default.
- NCIT_C188056 NCIT_P208 "CL1792833" @default.
- NCIT_C188056 NCIT_P399 "809857" @default.
- NCIT_C188056 normalizedInformationContent "100" @default.
- NCIT_C188056 referenceCount "1" @default.
- NCIT_C188056 hasExactSynonym "Allogeneic TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated NK Cells" @default.
- NCIT_C188056 hasExactSynonym "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated NK Cells" @default.
- NCIT_C188056 hasExactSynonym "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells" @default.
- NCIT_C188056 hasExactSynonym "TCR AlphaBeta/CD19-depleted DEA-NK Cells" @default.
- NCIT_C188056 hasExactSynonym "TCR AlphaBeta/CD19-depleted Donor Enriched Activated Natural Killer Cells" @default.
- NCIT_C188056 inSubset NCIT_C128784 @default.
- NCIT_C188056 inSubset NCIT_C176424 @default.
- NCIT_C188056 type Class @default.
- NCIT_C188056 isDefinedBy ncit.owl @default.
- NCIT_C188056 label "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells" @default.
- NCIT_C188056 subClassOf NCIT_C129820 @default.
- NCIT_C188056 subClassOf NCIT_C129821 @default.
- NCIT_C188056 subClassOf NCIT_C129826 @default.
- NCIT_C188056 subClassOf NCIT_C142078 @default.
- NCIT_C188056 subClassOf NCIT_C188056 @default.
- NCIT_C188056 subClassOf NCIT_C1908 @default.
- NCIT_C188056 subClassOf NCIT_C1909 @default.
- NCIT_C188056 subClassOf NCIT_C201545 @default.
- NCIT_C188056 subClassOf NCIT_C274 @default.
- NCIT_C188056 subClassOf NCIT_C28676 @default.
- NCIT_C188056 subClassOf NCIT_C307 @default.
- NCIT_C188056 subClassOf NCIT_C308 @default.