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- NCIT_C188057 IAO_0000115 "A recombinant bispecific antibody prodrug composed of a bispecific antibody directed against the tumor-associated antigen (TAA) human epidermal growth factor receptor (EGFR; HER1; ErbB1) and the human T-cell surface antigen CD3 that is linked to a proprietary masking peptide through a protease-cleavable linker, with potential immunostimulating and antineoplastic activities. Upon administration of protease-activated anti-EGFR/anti-CD3 bispecific antibody prodrug CX-904, the linkage system is stable in the circulation and, upon extravasation into the tumor microenvironment (TME), the peptide mask is cleaved by tumor-associated proteases. These proteases are present in high concentrations and aberrantly activated in the TME, while expressed as inactive forms, at much lower concentrations, in normal, healthy tissue. Protease cleavage of the linker enables binding of the unmasked, fully active bispecific antibody moiety of CX-904 to both CD3 on cytotoxic T-lymphocytes (CTLs) and EGFR on EGFR-expressing tumor cells. This activates and redirects CTLs to EGFR-expressing tumor cells, leading to CTL-mediated killing of EGFR-expressing tumor cells. EGFR, upregulated and/or mutated in a variety of tumor cell types, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C188057 NCIT_A7 NCIT_C17068 @default.
- NCIT_C188057 NCIT_NHC0 "C188057" @default.
- NCIT_C188057 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188057 NCIT_P107 "Protease-activated Anti-EGFR/Anti-CD3 Bispecific Antibody Prodrug CX-904" @default.
- NCIT_C188057 NCIT_P108 "Protease-activated Anti-EGFR/Anti-CD3 Bispecific Antibody Prodrug CX-904" @default.
- NCIT_C188057 NCIT_P208 "CL1792834" @default.
- NCIT_C188057 NCIT_P322 "CTRP" @default.
- NCIT_C188057 NCIT_P322 "GDC" @default.
- NCIT_C188057 NCIT_P399 "809868" @default.
- NCIT_C188057 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188057 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188057 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188057 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188057 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188057 normalizedInformationContent "100" @default.
- NCIT_C188057 referenceCount "1" @default.
- NCIT_C188057 hasExactSynonym "AMG 651" @default.
- NCIT_C188057 hasExactSynonym "AMG-651" @default.
- NCIT_C188057 hasExactSynonym "AMG651" @default.
- NCIT_C188057 hasExactSynonym "Anti-EGFR/Anti-CD3 Bispecific Probody AMG 651" @default.
- NCIT_C188057 hasExactSynonym "Anti-EGFR/Anti-CD3 Bispecific Probody CX-904" @default.
- NCIT_C188057 hasExactSynonym "Anti-EGFR/Anti-CD3 T-cell Engaging Bispecific Probody AMG 651" @default.
- NCIT_C188057 hasExactSynonym "Anti-EGFR/Anti-CD3 T-cell Engaging Bispecific Probody CX-904" @default.
- NCIT_C188057 hasExactSynonym "Anti-EGFR/CD3 Bispecific Antibody Prodrug CX-904" @default.
- NCIT_C188057 hasExactSynonym "CX 904" @default.
- NCIT_C188057 hasExactSynonym "CX-904" @default.
- NCIT_C188057 hasExactSynonym "CX904" @default.
- NCIT_C188057 hasExactSynonym "EGFR x CD3 Bispecific Antibody Prodrug CX-904" @default.
- NCIT_C188057 hasExactSynonym "Protease-activated Anti-EGFR/Anti-CD3 Bispecific Antibody Prodrug CX-904" @default.
- NCIT_C188057 hasExactSynonym "T-cell-engaging Bispecific Antibody CX-904" @default.
- NCIT_C188057 hasExactSynonym "TCB Antibody CX-904" @default.
- NCIT_C188057 inSubset NCIT_C116977 @default.
- NCIT_C188057 inSubset NCIT_C116978 @default.
- NCIT_C188057 inSubset NCIT_C128784 @default.
- NCIT_C188057 inSubset NCIT_C157711 @default.
- NCIT_C188057 inSubset NCIT_C157712 @default.
- NCIT_C188057 inSubset NCIT_C176424 @default.
- NCIT_C188057 type Class @default.
- NCIT_C188057 isDefinedBy ncit.owl @default.
- NCIT_C188057 label "Protease-activated Anti-EGFR/Anti-CD3 Bispecific Antibody Prodrug CX-904" @default.
- NCIT_C188057 subClassOf NCIT_C112883 @default.
- NCIT_C188057 subClassOf NCIT_C133878 @default.
- NCIT_C188057 subClassOf NCIT_C1454 @default.
- NCIT_C188057 subClassOf NCIT_C163758 @default.
- NCIT_C188057 subClassOf NCIT_C163952 @default.
- NCIT_C188057 subClassOf NCIT_C188057 @default.
- NCIT_C188057 subClassOf NCIT_C1908 @default.
- NCIT_C188057 subClassOf NCIT_C1909 @default.
- NCIT_C188057 subClassOf NCIT_C201282 @default.
- NCIT_C188057 subClassOf NCIT_C20401 @default.
- NCIT_C188057 subClassOf NCIT_C274 @default.
- NCIT_C188057 subClassOf NCIT_C28227 @default.
- NCIT_C188057 subClassOf NCIT_C307 @default.
- NCIT_C188057 subClassOf NCIT_C308 @default.