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- NCIT_C188123 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, BCMA-targeted LCAR-BCDR cells specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells." @default.
- NCIT_C188123 NCIT_A7 NCIT_C97848 @default.
- NCIT_C188123 NCIT_NHC0 "C188123" @default.
- NCIT_C188123 NCIT_P106 "Cell" @default.
- NCIT_C188123 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188123 NCIT_P108 "BCMA-targeted LCAR-BCDR Cells" @default.
- NCIT_C188123 NCIT_P208 "CL1792775" @default.
- NCIT_C188123 NCIT_P322 "GDC" @default.
- NCIT_C188123 NCIT_P399 "809846" @default.
- NCIT_C188123 normalizedInformationContent "100" @default.
- NCIT_C188123 referenceCount "1" @default.
- NCIT_C188123 hasExactSynonym "Anti-BCMA LCAR-BCDR Cells" @default.
- NCIT_C188123 hasExactSynonym "BCMA-targeted LCAR-BCDR Cells" @default.
- NCIT_C188123 hasExactSynonym "LCAR-BCDR Cells" @default.
- NCIT_C188123 inSubset NCIT_C128784 @default.
- NCIT_C188123 inSubset NCIT_C157711 @default.
- NCIT_C188123 inSubset NCIT_C157712 @default.
- NCIT_C188123 inSubset NCIT_C176424 @default.
- NCIT_C188123 type Class @default.
- NCIT_C188123 isDefinedBy ncit.owl @default.
- NCIT_C188123 label "BCMA-targeted LCAR-BCDR Cells" @default.
- NCIT_C188123 subClassOf NCIT_C129820 @default.
- NCIT_C188123 subClassOf NCIT_C129821 @default.
- NCIT_C188123 subClassOf NCIT_C129826 @default.
- NCIT_C188123 subClassOf NCIT_C137999 @default.
- NCIT_C188123 subClassOf NCIT_C142078 @default.
- NCIT_C188123 subClassOf NCIT_C154231 @default.
- NCIT_C188123 subClassOf NCIT_C176023 @default.
- NCIT_C188123 subClassOf NCIT_C188123 @default.
- NCIT_C188123 subClassOf NCIT_C1908 @default.
- NCIT_C188123 subClassOf NCIT_C1909 @default.
- NCIT_C188123 subClassOf NCIT_C1962 @default.
- NCIT_C188123 subClassOf NCIT_C274 @default.
- NCIT_C188123 subClassOf NCIT_C307 @default.
- NCIT_C188123 subClassOf NCIT_C308 @default.