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- NCIT_C188201 IAO_0000115 "A bispecific antibody directed against both the T-cell surface antigen CD3 and the tumor-associated antigen (TAA) CD33, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD33/CD3 bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and CD33 on CD33-expressing tumor cells, thereby crosslinking tumor cells and CTLs. This activates and redirects CTLs to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem and progenitor cells (HSPCs) and is overexpressed on a variety of cancer cell types, including acute myeloid leukemia (AML). It plays a key role in tumor initiation, proliferation and progression." @default.
- NCIT_C188201 NCIT_A7 NCIT_C97246 @default.
- NCIT_C188201 NCIT_NHC0 "C188201" @default.
- NCIT_C188201 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188201 NCIT_P107 "Anti-CD33/CD3 Bispecific Antibody" @default.
- NCIT_C188201 NCIT_P108 "Anti-CD33/CD3 Bispecific Antibody" @default.
- NCIT_C188201 NCIT_P208 "CL1793119" @default.
- NCIT_C188201 NCIT_P322 "CTRP" @default.
- NCIT_C188201 NCIT_P399 "801516" @default.
- NCIT_C188201 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188201 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188201 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188201 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188201 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188201 normalizedInformationContent "100" @default.
- NCIT_C188201 referenceCount "1" @default.
- NCIT_C188201 hasExactSynonym "Anti-CD33/Anti-CD3 Bispecific Antibody" @default.
- NCIT_C188201 hasExactSynonym "Anti-CD33/CD3 Bispecific Antibody" @default.
- NCIT_C188201 hasExactSynonym "CD33 x CD3 Bispecific Antibody" @default.
- NCIT_C188201 hasExactSynonym "CD33xCD3 BsAb" @default.
- NCIT_C188201 inSubset NCIT_C116977 @default.
- NCIT_C188201 inSubset NCIT_C116978 @default.
- NCIT_C188201 inSubset NCIT_C128784 @default.
- NCIT_C188201 inSubset NCIT_C176424 @default.
- NCIT_C188201 type Class @default.
- NCIT_C188201 isDefinedBy ncit.owl @default.
- NCIT_C188201 label "Anti-CD33/CD3 Bispecific Antibody" @default.
- NCIT_C188201 subClassOf NCIT_C112883 @default.
- NCIT_C188201 subClassOf NCIT_C129821 @default.
- NCIT_C188201 subClassOf NCIT_C129822 @default.
- NCIT_C188201 subClassOf NCIT_C1454 @default.
- NCIT_C188201 subClassOf NCIT_C188201 @default.
- NCIT_C188201 subClassOf NCIT_C1908 @default.
- NCIT_C188201 subClassOf NCIT_C1909 @default.
- NCIT_C188201 subClassOf NCIT_C200367 @default.
- NCIT_C188201 subClassOf NCIT_C201282 @default.
- NCIT_C188201 subClassOf NCIT_C20401 @default.
- NCIT_C188201 subClassOf NCIT_C274 @default.
- NCIT_C188201 subClassOf NCIT_C28227 @default.
- NCIT_C188201 subClassOf NCIT_C307 @default.
- NCIT_C188201 subClassOf NCIT_C308 @default.