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- NCIT_C188231 IAO_0000115 "An orally bioavailable inhibitor of the oncogenic KRAS substitution mutation G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor D3S-001 selectively targets the KRAS G12C mutant and inhibits KRAS G12C-mediated signaling. This may halt proliferation and metastasis in susceptible tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis." @default.
- NCIT_C188231 NCIT_A7 NCIT_C98365 @default.
- NCIT_C188231 NCIT_NHC0 "C188231" @default.
- NCIT_C188231 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188231 NCIT_P108 "KRAS G12C Inhibitor D3S-001" @default.
- NCIT_C188231 NCIT_P208 "CL1793078" @default.
- NCIT_C188231 NCIT_P322 "GDC" @default.
- NCIT_C188231 NCIT_P399 "810067" @default.
- NCIT_C188231 normalizedInformationContent "100" @default.
- NCIT_C188231 referenceCount "1" @default.
- NCIT_C188231 hasExactSynonym "D3S 001" @default.
- NCIT_C188231 hasExactSynonym "D3S-001" @default.
- NCIT_C188231 hasExactSynonym "D3S001" @default.
- NCIT_C188231 hasExactSynonym "KRAS G12C Inhibitor D3S-001" @default.
- NCIT_C188231 inSubset NCIT_C128784 @default.
- NCIT_C188231 inSubset NCIT_C157711 @default.
- NCIT_C188231 inSubset NCIT_C157712 @default.
- NCIT_C188231 inSubset NCIT_C176424 @default.
- NCIT_C188231 type Class @default.
- NCIT_C188231 isDefinedBy ncit.owl @default.
- NCIT_C188231 label "KRAS G12C Inhibitor D3S-001" @default.
- NCIT_C188231 subClassOf NCIT_C163758 @default.
- NCIT_C188231 subClassOf NCIT_C188231 @default.
- NCIT_C188231 subClassOf NCIT_C1902 @default.
- NCIT_C188231 subClassOf NCIT_C1908 @default.
- NCIT_C188231 subClassOf NCIT_C1909 @default.
- NCIT_C188231 subClassOf NCIT_C200729 @default.
- NCIT_C188231 subClassOf NCIT_C2189 @default.
- NCIT_C188231 subClassOf NCIT_C274 @default.