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- NCIT_C188237 IAO_0000115 "An orally bioavailable central nervous system (CNS) penetrant and inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1, with potential antineoplastic activity. Upon oral administration, PARP1 inhibitor AZD9574 selectively binds to PARP1, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. AZD9574 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks and double-strand break (DSBs). AZD9574 is able to penetrate the blood-brain barrier (BBB)." @default.
- NCIT_C188237 NCIT_A7 NCIT_C104720 @default.
- NCIT_C188237 NCIT_A7 NCIT_C48215 @default.
- NCIT_C188237 NCIT_NHC0 "C188237" @default.
- NCIT_C188237 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188237 NCIT_P108 "PARP1 Inhibitor AZD9574" @default.
- NCIT_C188237 NCIT_P208 "CL1793069" @default.
- NCIT_C188237 NCIT_P210 "2756333-39-6" @default.
- NCIT_C188237 NCIT_P322 "GDC" @default.
- NCIT_C188237 NCIT_P399 "810056" @default.
- NCIT_C188237 NCIT_R146 NCIT_C104101 @default.
- NCIT_C188237 NCIT_R146 NCIT_C16554 @default.
- NCIT_C188237 NCIT_R146 NCIT_C17021 @default.
- NCIT_C188237 NCIT_R146 NCIT_C17210 @default.
- NCIT_C188237 NCIT_R146 NCIT_C17434 @default.
- NCIT_C188237 NCIT_R146 NCIT_C20027 @default.
- NCIT_C188237 NCIT_R146 NCIT_C21170 @default.
- NCIT_C188237 NCIT_R146 NCIT_C26548 @default.
- NCIT_C188237 NCIT_R146 NCIT_C48215 @default.
- NCIT_C188237 normalizedInformationContent "100" @default.
- NCIT_C188237 referenceCount "1" @default.
- NCIT_C188237 hasExactSynonym "6-Fluoro-5-[4-[(5-Fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide" @default.
- NCIT_C188237 hasExactSynonym "AZD 9574" @default.
- NCIT_C188237 hasExactSynonym "AZD-9574" @default.
- NCIT_C188237 hasExactSynonym "AZD9574" @default.
- NCIT_C188237 hasExactSynonym "PARP Inhibitor TQB3823" @default.
- NCIT_C188237 hasExactSynonym "PARP1 Inhibitor AZD9574" @default.
- NCIT_C188237 inSubset NCIT_C128784 @default.
- NCIT_C188237 inSubset NCIT_C157711 @default.
- NCIT_C188237 inSubset NCIT_C157712 @default.
- NCIT_C188237 inSubset NCIT_C176424 @default.
- NCIT_C188237 type Class @default.
- NCIT_C188237 isDefinedBy ncit.owl @default.
- NCIT_C188237 label "PARP1 Inhibitor AZD9574" @default.
- NCIT_C188237 subClassOf NCIT_C163758 @default.
- NCIT_C188237 subClassOf NCIT_C188237 @default.
- NCIT_C188237 subClassOf NCIT_C1908 @default.
- NCIT_C188237 subClassOf NCIT_C1909 @default.
- NCIT_C188237 subClassOf NCIT_C274 @default.
- NCIT_C188237 subClassOf NCIT_C471 @default.
- NCIT_C188237 subClassOf NCIT_C62554 @default.