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- NCIT_C188255 IAO_0000115 "The adipate form of zeteletinib, an orally bioavailable selective inhibitor of wild-type, fusion products and mutated forms, including gatekeeper mutations, of the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, zeteletinib selectively binds to and inhibits the activity of RET. This results in an inhibition of cell growth of tumors cells that exhibit increased RET activity. RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers." @default.
- NCIT_C188255 NCIT_A7 NCIT_C18539 @default.
- NCIT_C188255 NCIT_NHC0 "C188255" @default.
- NCIT_C188255 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188255 NCIT_P108 "Zeteletinib Adipate" @default.
- NCIT_C188255 NCIT_P208 "CL1793107" @default.
- NCIT_C188255 NCIT_P210 "2375837-06-0" @default.
- NCIT_C188255 NCIT_P319 "EW27AA6XBH" @default.
- NCIT_C188255 NCIT_P322 "FDA" @default.
- NCIT_C188255 normalizedInformationContent "100" @default.
- NCIT_C188255 referenceCount "1" @default.
- NCIT_C188255 hasExactSynonym "BOS 172738 Adipate" @default.
- NCIT_C188255 hasExactSynonym "BOS-172738 Adipate" @default.
- NCIT_C188255 hasExactSynonym "BOS172738 Adipate" @default.
- NCIT_C188255 hasExactSynonym "DS 5010" @default.
- NCIT_C188255 hasExactSynonym "DS-5010" @default.
- NCIT_C188255 hasExactSynonym "DS5010" @default.
- NCIT_C188255 hasExactSynonym "RET Inhibitor DS-5010" @default.
- NCIT_C188255 hasExactSynonym "ZETELETINIB ADIPATE" @default.
- NCIT_C188255 hasExactSynonym "Zeteletinib Adipate" @default.
- NCIT_C188255 hasExactSynonym "Zeteletinib Hemiadipate" @default.
- NCIT_C188255 inSubset NCIT_C128784 @default.
- NCIT_C188255 inSubset NCIT_C63923 @default.
- NCIT_C188255 type Class @default.
- NCIT_C188255 isDefinedBy ncit.owl @default.
- NCIT_C188255 label "Zeteletinib Adipate" @default.
- NCIT_C188255 subClassOf NCIT_C129824 @default.
- NCIT_C188255 subClassOf NCIT_C129825 @default.
- NCIT_C188255 subClassOf NCIT_C1404 @default.
- NCIT_C188255 subClassOf NCIT_C159438 @default.
- NCIT_C188255 subClassOf NCIT_C163758 @default.
- NCIT_C188255 subClassOf NCIT_C188255 @default.
- NCIT_C188255 subClassOf NCIT_C1908 @default.
- NCIT_C188255 subClassOf NCIT_C1909 @default.
- NCIT_C188255 subClassOf NCIT_C1967 @default.
- NCIT_C188255 subClassOf NCIT_C2189 @default.
- NCIT_C188255 subClassOf NCIT_C274 @default.
- NCIT_C188255 subClassOf NCIT_C471 @default.