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- NCIT_C188287 IAO_0000115 "A T-cell receptor (TCR)-like T-cell engaging bispecific antibody (T-BsAb) targeting both the RMFPNAPYL nonapeptide (RMF peptide), which is derived from the intracellular Wilms tumor 1 (WT1; WT-1) and presented on human leukocyte antigen A2 (HLA-A2), and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-HLA-A2-WT1/anti-CD3 T-cell engaging bispecific antibody RO7283420 simultaneously binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and the HLA-A2 WT1 complex found on WT1-expressing tumor cells. This activates and redirects CTLs to WT1-expressing tumor cells, which results in the CTL-mediated cell death of WT1-expressing tumor cells. WT1, an intracellular oncoprotein and transcription factor, is overexpressed in a variety of tumor cell types." @default.
- NCIT_C188287 NCIT_A7 NCIT_C17549 @default.
- NCIT_C188287 NCIT_NHC0 "C188287" @default.
- NCIT_C188287 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188287 NCIT_P107 "Anti-HLA-A2-WT1/Anti-CD3 T-cell Engaging Bispecific Antibody RO7283420" @default.
- NCIT_C188287 NCIT_P108 "Anti-HLA-A2-WT1/Anti-CD3 T-cell Engaging Bispecific Antibody RO7283420" @default.
- NCIT_C188287 NCIT_P208 "CL1793043" @default.
- NCIT_C188287 NCIT_P322 "CTRP" @default.
- NCIT_C188287 NCIT_P322 "GDC" @default.
- NCIT_C188287 NCIT_P399 "804575" @default.
- NCIT_C188287 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188287 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188287 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188287 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188287 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188287 normalizedInformationContent "100" @default.
- NCIT_C188287 referenceCount "1" @default.
- NCIT_C188287 hasExactSynonym "Anti-HLA-A2-WT1/Anti-CD3 T-cell Engaging Bispecific Antibody RO7283420" @default.
- NCIT_C188287 hasExactSynonym "HLA-A2-WT1 x CD3 RG6007" @default.
- NCIT_C188287 hasExactSynonym "HLA-A2-WT1xCD3 T-cell Engaging Bispecific Antibody RO7283420" @default.
- NCIT_C188287 hasExactSynonym "RG 6007" @default.
- NCIT_C188287 hasExactSynonym "RG-06007" @default.
- NCIT_C188287 hasExactSynonym "RG6007" @default.
- NCIT_C188287 hasExactSynonym "RMF-peptide-MHC-specific T-cell Bispecific Antibody RG6007" @default.
- NCIT_C188287 hasExactSynonym "RO 7283420" @default.
- NCIT_C188287 hasExactSynonym "RO-7283420" @default.
- NCIT_C188287 hasExactSynonym "RO7283420" @default.
- NCIT_C188287 inSubset NCIT_C116977 @default.
- NCIT_C188287 inSubset NCIT_C116978 @default.
- NCIT_C188287 inSubset NCIT_C128784 @default.
- NCIT_C188287 inSubset NCIT_C157711 @default.
- NCIT_C188287 inSubset NCIT_C157712 @default.
- NCIT_C188287 inSubset NCIT_C176424 @default.
- NCIT_C188287 type Class @default.
- NCIT_C188287 isDefinedBy ncit.owl @default.
- NCIT_C188287 label "Anti-HLA-A2-WT1/Anti-CD3 T-cell Engaging Bispecific Antibody RO7283420" @default.
- NCIT_C188287 subClassOf NCIT_C112883 @default.
- NCIT_C188287 subClassOf NCIT_C129821 @default.
- NCIT_C188287 subClassOf NCIT_C129822 @default.
- NCIT_C188287 subClassOf NCIT_C1454 @default.
- NCIT_C188287 subClassOf NCIT_C188287 @default.
- NCIT_C188287 subClassOf NCIT_C1908 @default.
- NCIT_C188287 subClassOf NCIT_C1909 @default.
- NCIT_C188287 subClassOf NCIT_C201282 @default.
- NCIT_C188287 subClassOf NCIT_C20401 @default.
- NCIT_C188287 subClassOf NCIT_C274 @default.
- NCIT_C188287 subClassOf NCIT_C28227 @default.
- NCIT_C188287 subClassOf NCIT_C307 @default.
- NCIT_C188287 subClassOf NCIT_C308 @default.