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- NCIT_C1883 IAO_0000115 "A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated." @default.
- NCIT_C1883 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1883 NCIT_NHC0 "C1883" @default.
- NCIT_C1883 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1883 NCIT_P108 "Vitamin D3 Analogue ILX23-7553" @default.
- NCIT_C1883 NCIT_P207 "C0966846" @default.
- NCIT_C1883 NCIT_P210 "118694-43-2" @default.
- NCIT_C1883 NCIT_P319 "O13QTC8612" @default.
- NCIT_C1883 NCIT_P322 "FDA" @default.
- NCIT_C1883 NCIT_P322 "GDC" @default.
- NCIT_C1883 NCIT_P325 "A substance that is being studied as an anticancer drug." @default.
- NCIT_C1883 NCIT_P329 "37861" @default.
- NCIT_C1883 NCIT_P330 "37861" @default.
- NCIT_C1883 NCIT_P366 "ILX23-7553" @default.
- NCIT_C1883 NCIT_P375 "Vitamin D3 Analogue ILX23-7553" @default.
- NCIT_C1883 NCIT_P399 "37861" @default.
- NCIT_C1883 normalizedInformationContent "100" @default.
- NCIT_C1883 referenceCount "1" @default.
- NCIT_C1883 hasExactSynonym "1,25-dihydroxy-16-ene-23-yne-cholecalciferol" @default.
- NCIT_C1883 hasExactSynonym "16-23-D3" @default.
- NCIT_C1883 hasExactSynonym "9,10-Secocholesta-5,7,10(19),16-tetraen-23-yne-1,3,25-triol, (1alpha,3beta,5Z,7E)-" @default.
- NCIT_C1883 hasExactSynonym "BXL 353" @default.
- NCIT_C1883 hasExactSynonym "ILEX 23-7553" @default.
- NCIT_C1883 hasExactSynonym "ILX 237553" @default.
- NCIT_C1883 hasExactSynonym "ILX-237553" @default.
- NCIT_C1883 hasExactSynonym "ILX23-7553" @default.
- NCIT_C1883 hasExactSynonym "ILX237553" @default.
- NCIT_C1883 hasExactSynonym "RO 237553" @default.
- NCIT_C1883 hasExactSynonym "RO-23-7553" @default.
- NCIT_C1883 hasExactSynonym "RO-237553" @default.
- NCIT_C1883 hasExactSynonym "RO237553" @default.
- NCIT_C1883 hasExactSynonym "Ro23-7553" @default.
- NCIT_C1883 hasExactSynonym "Vitamin D3 Analogue ILX23-7553" @default.
- NCIT_C1883 inSubset NCIT_C128784 @default.
- NCIT_C1883 inSubset NCIT_C157711 @default.
- NCIT_C1883 inSubset NCIT_C157712 @default.
- NCIT_C1883 inSubset NCIT_C176424 @default.
- NCIT_C1883 inSubset NCIT_C177537 @default.
- NCIT_C1883 inSubset NCIT_C63923 @default.
- NCIT_C1883 type Class @default.
- NCIT_C1883 isDefinedBy ncit.owl @default.
- NCIT_C1883 label "Vitamin D3 Analogue ILX23-7553" @default.
- NCIT_C1883 subClassOf NCIT_C1883 @default.
- NCIT_C1883 subClassOf NCIT_C1908 @default.
- NCIT_C1883 subClassOf NCIT_C1909 @default.
- NCIT_C1883 subClassOf NCIT_C1934 @default.
- NCIT_C1883 subClassOf NCIT_C2122 @default.
- NCIT_C1883 subClassOf NCIT_C274 @default.