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- NCIT_C188303 IAO_0000115 "A fixed combination of nirmatrelvir, an inhibitor of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) main protease (Mpro; 3C-like protease; 3CL protease; 3CLpro; nsp5 protease), and ritonavir, an inhibitor of cytochrome P450 3A4 (CYP3A4), that may be used to treat coronavirus disease 2019 (COVID-19). Upon oral administration of nirmatrelvir/ritonavir, nirmatrelvir selectively targets, binds to, and inhibits the activity of SARS-CoV-2 Mpro. This inhibits the proteolytic cleavage of viral polyproteins, thereby inhibiting the formation of viral proteins including helicase, single-stranded-RNA-binding protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease and exoribonuclease. This prevents viral transcription and replication. Ritonavir inhibits CYP3A4-mediated metabolism of nirmatrelvir, thereby increasing the plasma concentration of nirmatrelvir." @default.
- NCIT_C188303 NCIT_A48 NCIT_C17998 @default.
- NCIT_C188303 NCIT_A48 NCIT_C49487 @default.
- NCIT_C188303 NCIT_A48 NCIT_C49488 @default.
- NCIT_C188303 NCIT_NHC0 "C188303" @default.
- NCIT_C188303 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188303 NCIT_P108 "Nirmatrelvir/Ritonavir" @default.
- NCIT_C188303 NCIT_P208 "CL1793033" @default.
- NCIT_C188303 NCIT_P322 "ACC/AHA" @default.
- NCIT_C188303 NCIT_P325 "Nirmatrelvir inhibits the SARS-CoV-2 main protease (Mpro), which results in inhibition of viral replication. Ritonavir has no direct activity against SARS-CoV-2 but is a pharmacokinetic boosting agent that results in higher plasma concentrations of nirmatrelvir." @default.
- NCIT_C188303 normalizedInformationContent "100" @default.
- NCIT_C188303 referenceCount "1" @default.
- NCIT_C188303 hasExactSynonym "Nirmatrelvir/Ritonavir" @default.
- NCIT_C188303 hasExactSynonym "Paxlovid" @default.
- NCIT_C188303 hasExactSynonym "Ritonavir/Nirmatrelvir" @default.
- NCIT_C188303 hasExactSynonym "SARS-CoV-2 protease inhibitors: nirmatrelvir/ritonavir" @default.
- NCIT_C188303 inSubset NCIT_C173381 @default.
- NCIT_C188303 inSubset NCIT_C173383 @default.
- NCIT_C188303 inSubset NCIT_C191200 @default.
- NCIT_C188303 inSubset NCIT_C191387 @default.
- NCIT_C188303 inSubset NCIT_C191404 @default.
- NCIT_C188303 inSubset NCIT_C191670 @default.
- NCIT_C188303 type Class @default.
- NCIT_C188303 isDefinedBy ncit.owl @default.
- NCIT_C188303 label "Nirmatrelvir/Ritonavir" @default.
- NCIT_C188303 subClassOf NCIT_C188303 @default.
- NCIT_C188303 subClassOf NCIT_C190794 @default.
- NCIT_C188303 subClassOf NCIT_C190795 @default.
- NCIT_C188303 subClassOf NCIT_C1908 @default.
- NCIT_C188303 subClassOf NCIT_C1909 @default.
- NCIT_C188303 subClassOf NCIT_C254 @default.
- NCIT_C188303 subClassOf NCIT_C281 @default.
- NCIT_C188303 subClassOf NCIT_C471 @default.
- NCIT_C188303 subClassOf NCIT_C783 @default.