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- NCIT_C188306 IAO_0000115 "A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated, through a bifunctional, macrocyclic chelating agent DOTAM (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic amide; TCMC), to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212 DOTAMTATE targets and binds to somatostatin receptors (SSTRs) present on the cell membranes of most types of neuroendocrine tumor (NET) cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to SSTR-positive cells. TATE is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs." @default.
- NCIT_C188306 NCIT_A7 NCIT_C17333 @default.
- NCIT_C188306 NCIT_NHC0 "C188306" @default.
- NCIT_C188306 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C188306 NCIT_P107 "Lead Pb 212 DOTAMTATE" @default.
- NCIT_C188306 NCIT_P108 "Lead Pb 212 DOTAMTATE" @default.
- NCIT_C188306 NCIT_P208 "CL1793036" @default.
- NCIT_C188306 NCIT_P322 "CTRP" @default.
- NCIT_C188306 NCIT_P322 "GDC" @default.
- NCIT_C188306 NCIT_P399 "810241" @default.
- NCIT_C188306 normalizedInformationContent "100" @default.
- NCIT_C188306 referenceCount "1" @default.
- NCIT_C188306 hasExactSynonym "212Pb-DOTAMTATE" @default.
- NCIT_C188306 hasExactSynonym "AlphaMedix" @default.
- NCIT_C188306 hasExactSynonym "Lead Pb 212 DOTAMTATE" @default.
- NCIT_C188306 hasExactSynonym "Pb212-DOTAMTATE" @default.
- NCIT_C188306 inSubset NCIT_C116977 @default.
- NCIT_C188306 inSubset NCIT_C116978 @default.
- NCIT_C188306 inSubset NCIT_C157711 @default.
- NCIT_C188306 inSubset NCIT_C157712 @default.
- NCIT_C188306 inSubset NCIT_C176424 @default.
- NCIT_C188306 type Class @default.
- NCIT_C188306 isDefinedBy ncit.owl @default.
- NCIT_C188306 label "Lead Pb 212 DOTAMTATE" @default.
- NCIT_C188306 subClassOf NCIT_C129819 @default.
- NCIT_C188306 subClassOf NCIT_C1446 @default.
- NCIT_C188306 subClassOf NCIT_C188306 @default.
- NCIT_C188306 subClassOf NCIT_C1908 @default.
- NCIT_C188306 subClassOf NCIT_C1909 @default.
- NCIT_C188306 subClassOf NCIT_C200225 @default.
- NCIT_C188306 subClassOf NCIT_C2124 @default.
- NCIT_C188306 subClassOf NCIT_C274 @default.