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- NCIT_C188311 IAO_0000115 "A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the natural-killer group 2, member D receptor protein (NKG2D or KLRK1) ligands MHC class I polypeptide-related sequence A (MICA) and B (MICB), with potential immunostimulating and antineoplastic activities. Upon administration, anti-MICA/MICB monoclonal antibody CLN-619 targets and binds to the alpha3 domain of MICA and MICB, and prevents the cleavage of MICA and MICB from the cell surface of tumor cells by proteases in the tumor microenvironment (TME). This enhances the binding of NKG2D-expressing immune cells, including natural killer (NK) cells and subset of T-cells, to MICA- and MICB-expressing tumor cells, which leads to the activation of NK cells and the lysis of tumor cells. CLN-619 also enhances antitumor response through antibody-dependent cell-mediated cytotoxicity (ADCC). MICA and MICB are stress-induced NKG2D ligands overexpressed on infected cells and many cancer cell types, but are not expressed on most normal, healthy cells. The shedding of MICA and MICB from tumor cell surface allows the tumor cells to evade NKG2D-expressing immune cells." @default.
- NCIT_C188311 NCIT_A7 NCIT_C104650 @default.
- NCIT_C188311 NCIT_A7 NCIT_C126961 @default.
- NCIT_C188311 NCIT_NHC0 "C188311" @default.
- NCIT_C188311 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188311 NCIT_P107 "Anti-MICA/MICB Monoclonal Antibody CLN-619" @default.
- NCIT_C188311 NCIT_P108 "Anti-MICA/MICB Monoclonal Antibody CLN-619" @default.
- NCIT_C188311 NCIT_P208 "CL1793026" @default.
- NCIT_C188311 NCIT_P322 "CTRP" @default.
- NCIT_C188311 NCIT_P322 "GDC" @default.
- NCIT_C188311 NCIT_P399 "810240" @default.
- NCIT_C188311 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188311 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188311 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188311 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188311 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188311 normalizedInformationContent "100" @default.
- NCIT_C188311 referenceCount "1" @default.
- NCIT_C188311 hasExactSynonym "Anti-MICA/MICB Monoclonal Antibody CLN-619" @default.
- NCIT_C188311 hasExactSynonym "CLN 619" @default.
- NCIT_C188311 hasExactSynonym "CLN-619" @default.
- NCIT_C188311 hasExactSynonym "CLN619" @default.
- NCIT_C188311 inSubset NCIT_C116977 @default.
- NCIT_C188311 inSubset NCIT_C116978 @default.
- NCIT_C188311 inSubset NCIT_C128784 @default.
- NCIT_C188311 inSubset NCIT_C157711 @default.
- NCIT_C188311 inSubset NCIT_C157712 @default.
- NCIT_C188311 inSubset NCIT_C176424 @default.
- NCIT_C188311 type Class @default.
- NCIT_C188311 isDefinedBy ncit.owl @default.
- NCIT_C188311 label "Anti-MICA/MICB Monoclonal Antibody CLN-619" @default.
- NCIT_C188311 subClassOf NCIT_C129821 @default.
- NCIT_C188311 subClassOf NCIT_C129822 @default.
- NCIT_C188311 subClassOf NCIT_C188311 @default.
- NCIT_C188311 subClassOf NCIT_C1908 @default.
- NCIT_C188311 subClassOf NCIT_C1909 @default.
- NCIT_C188311 subClassOf NCIT_C20401 @default.
- NCIT_C188311 subClassOf NCIT_C274 @default.
- NCIT_C188311 subClassOf NCIT_C307 @default.
- NCIT_C188311 subClassOf NCIT_C308 @default.