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- NCIT_C188361 IAO_0000115 "A humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface antigen CD47, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD47 monoclonal antibody HMPL-A83 targets and binds to CD47 expressed on tumor cells, blocking the interaction of CD47 with signal regulatory protein alpha (SIRPa) expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of macrophage activation and phagocytosis of cancer cells. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), which is expressed on macrophages, and results in macrophage activation and the specific phagocytosis of tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate." @default.
- NCIT_C188361 NCIT_A7 NCIT_C25795 @default.
- NCIT_C188361 NCIT_NHC0 "C188361" @default.
- NCIT_C188361 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188361 NCIT_P108 "Anti-CD47 Monoclonal Antibody HMPL-A83" @default.
- NCIT_C188361 NCIT_P208 "CL1793603" @default.
- NCIT_C188361 NCIT_P322 "GDC" @default.
- NCIT_C188361 NCIT_P399 "810154" @default.
- NCIT_C188361 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188361 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188361 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188361 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188361 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188361 normalizedInformationContent "100" @default.
- NCIT_C188361 referenceCount "1" @default.
- NCIT_C188361 hasExactSynonym "Anti-CD47 Monoclonal Antibody HMPL-A83" @default.
- NCIT_C188361 hasExactSynonym "HMPL A83" @default.
- NCIT_C188361 hasExactSynonym "HMPL-A83" @default.
- NCIT_C188361 hasExactSynonym "HMPLA83" @default.
- NCIT_C188361 inSubset NCIT_C128784 @default.
- NCIT_C188361 inSubset NCIT_C157711 @default.
- NCIT_C188361 inSubset NCIT_C157712 @default.
- NCIT_C188361 inSubset NCIT_C176424 @default.
- NCIT_C188361 type Class @default.
- NCIT_C188361 isDefinedBy ncit.owl @default.
- NCIT_C188361 label "Anti-CD47 Monoclonal Antibody HMPL-A83" @default.
- NCIT_C188361 subClassOf B8213c4e721a274630714d1a5d6915ae6 @default.
- NCIT_C188361 subClassOf Baa707033891f6b29bffa87cb28eb45a5 @default.
- NCIT_C188361 subClassOf NCIT_C129821 @default.
- NCIT_C188361 subClassOf NCIT_C129822 @default.
- NCIT_C188361 subClassOf NCIT_C159583 @default.
- NCIT_C188361 subClassOf NCIT_C163758 @default.
- NCIT_C188361 subClassOf NCIT_C188361 @default.
- NCIT_C188361 subClassOf NCIT_C1908 @default.
- NCIT_C188361 subClassOf NCIT_C1909 @default.
- NCIT_C188361 subClassOf NCIT_C192655 @default.
- NCIT_C188361 subClassOf NCIT_C20401 @default.
- NCIT_C188361 subClassOf NCIT_C274 @default.
- NCIT_C188361 subClassOf NCIT_C307 @default.
- NCIT_C188361 subClassOf NCIT_C308 @default.