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- NCIT_C188378 IAO_0000115 "A radioconjugate composed of LM3, a human somatostatin receptor (SSTR) antagonist, conjugated to the albumin-binding dye Evans blue (EB) and linked to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against SSTR-expressing tumor cells. Upon administration, lutetium Lu 177-EB-LM3 targets and binds to SSTRs that are present on the cell membranes of many types of neuroendocrine tumors (NETs). Upon binding, SSTR-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. This agent also binds to serum albumin with its EB moiety which increases this agent's half-life and decreases its rate of clearance. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTRs." @default.
- NCIT_C188378 NCIT_A7 NCIT_C17333 @default.
- NCIT_C188378 NCIT_NHC0 "C188378" @default.
- NCIT_C188378 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188378 NCIT_P108 "Lutetium Lu 177-EB-LM3" @default.
- NCIT_C188378 NCIT_P208 "CL1793636" @default.
- NCIT_C188378 NCIT_P322 "GDC" @default.
- NCIT_C188378 NCIT_P399 "810112" @default.
- NCIT_C188378 normalizedInformationContent "100" @default.
- NCIT_C188378 referenceCount "1" @default.
- NCIT_C188378 hasExactSynonym "177Lu-EB-LM3" @default.
- NCIT_C188378 hasExactSynonym "177Lu-Evans Blue-modified LM3" @default.
- NCIT_C188378 hasExactSynonym "Lutetium Lu 177-EB-LM3" @default.
- NCIT_C188378 inSubset NCIT_C128784 @default.
- NCIT_C188378 inSubset NCIT_C157711 @default.
- NCIT_C188378 inSubset NCIT_C157712 @default.
- NCIT_C188378 inSubset NCIT_C176424 @default.
- NCIT_C188378 type Class @default.
- NCIT_C188378 isDefinedBy ncit.owl @default.
- NCIT_C188378 label "Lutetium Lu 177-EB-LM3" @default.
- NCIT_C188378 subClassOf NCIT_C129819 @default.
- NCIT_C188378 subClassOf NCIT_C1446 @default.
- NCIT_C188378 subClassOf NCIT_C188378 @default.
- NCIT_C188378 subClassOf NCIT_C1908 @default.
- NCIT_C188378 subClassOf NCIT_C1909 @default.
- NCIT_C188378 subClassOf NCIT_C2124 @default.
- NCIT_C188378 subClassOf NCIT_C274 @default.