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- NCIT_C188380 IAO_0000115 "An orally bioavailable central nervous system (CNS)-penetrant and inhibitor of certain inflammatory mediators, with potential neuroinflammation attenuating and neuroprotective activities. Upon oral administration, MW151 is able to penetrate the blood-brain-barrier (BBB) and inhibits the up-regulation of certain neuroinflammatory responses upon brain injury or caused by certain diseases. MW151 suppresses neuroinflammation-induced glial activation and prevents the production of certain pro-inflammatory cytokines, such as interleukin-1 beta (IL-1b) and tumor necrosis factor alpha (TNFa). By preventing the overproduction of inflammatory cytokines, over-activated neuroinflammatory pathways are attenuated and associative damage is decreased. This may slow down or prevent certain neurodegenerative disease and cognitive impairment. MW151 may also prevent damage to synapses and synaptic plasticity." @default.
- NCIT_C188380 NCIT_NHC0 "C188380" @default.
- NCIT_C188380 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C188380 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188380 NCIT_P108 "Neuroinflammatory Inhibitor MW151" @default.
- NCIT_C188380 NCIT_P208 "CL1793641" @default.
- NCIT_C188380 NCIT_P399 "810114" @default.
- NCIT_C188380 normalizedInformationContent "100" @default.
- NCIT_C188380 referenceCount "1" @default.
- NCIT_C188380 hasExactSynonym "2-(4-(4-Methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine" @default.
- NCIT_C188380 hasExactSynonym "Anti-neuroinflammatory Agent MW151" @default.
- NCIT_C188380 hasExactSynonym "MW 151" @default.
- NCIT_C188380 hasExactSynonym "MW-151" @default.
- NCIT_C188380 hasExactSynonym "MW01-2-151SRM" @default.
- NCIT_C188380 hasExactSynonym "MW151" @default.
- NCIT_C188380 hasExactSynonym "Neuroinflammatory Inhibitor MW151" @default.
- NCIT_C188380 inSubset NCIT_C176424 @default.
- NCIT_C188380 type Class @default.
- NCIT_C188380 isDefinedBy ncit.owl @default.
- NCIT_C188380 label "Neuroinflammatory Inhibitor MW151" @default.
- NCIT_C188380 subClassOf NCIT_C1509 @default.
- NCIT_C188380 subClassOf NCIT_C188380 @default.
- NCIT_C188380 subClassOf NCIT_C1908 @default.
- NCIT_C188380 subClassOf NCIT_C1909 @default.
- NCIT_C188380 subClassOf NCIT_C26170 @default.
- NCIT_C188380 subClassOf NCIT_C308 @default.