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- NCIT_C188381 IAO_0000115 "An orally bioavailable allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon oral administration, PRC2 inhibitor ORIC-944 targets and binds to the regulatory embryonic ectoderm development (EED) subunit of PRC2. This prevents the methyltransferase activity of PRC2, spefifically the methylation of histone 3 at lysine27 (H3K27). This depletes H3K27 trimethylation (H3K27me3) and modulates the expression of target genes. This may inhibit tumor cell proliferation. PRC2 is dysregulated in a variety of cancer cell types and is associated with poor prognosis. It is responsible for the methylation of H3K27 leading to transcriptional silencing. EED is essential for the histone methyltransferase activity of PRC2." @default.
- NCIT_C188381 NCIT_A7 NCIT_C101725 @default.
- NCIT_C188381 NCIT_A7 NCIT_C180426 @default.
- NCIT_C188381 NCIT_NHC0 "C188381" @default.
- NCIT_C188381 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188381 NCIT_P107 "PRC2 Inhibitor ORIC-944" @default.
- NCIT_C188381 NCIT_P108 "PRC2 Inhibitor ORIC-944" @default.
- NCIT_C188381 NCIT_P208 "CL1793640" @default.
- NCIT_C188381 NCIT_P322 "CTRP" @default.
- NCIT_C188381 NCIT_P322 "GDC" @default.
- NCIT_C188381 NCIT_P399 "810116" @default.
- NCIT_C188381 normalizedInformationContent "100" @default.
- NCIT_C188381 referenceCount "1" @default.
- NCIT_C188381 hasExactSynonym "ORIC 944" @default.
- NCIT_C188381 hasExactSynonym "ORIC-944" @default.
- NCIT_C188381 hasExactSynonym "ORIC944" @default.
- NCIT_C188381 hasExactSynonym "PRC2 Inhibitor ORIC-944" @default.
- NCIT_C188381 inSubset NCIT_C116977 @default.
- NCIT_C188381 inSubset NCIT_C116978 @default.
- NCIT_C188381 inSubset NCIT_C128784 @default.
- NCIT_C188381 inSubset NCIT_C157711 @default.
- NCIT_C188381 inSubset NCIT_C157712 @default.
- NCIT_C188381 inSubset NCIT_C176424 @default.
- NCIT_C188381 type Class @default.
- NCIT_C188381 isDefinedBy ncit.owl @default.
- NCIT_C188381 label "PRC2 Inhibitor ORIC-944" @default.
- NCIT_C188381 subClassOf NCIT_C129824 @default.
- NCIT_C188381 subClassOf NCIT_C188381 @default.
- NCIT_C188381 subClassOf NCIT_C1908 @default.
- NCIT_C188381 subClassOf NCIT_C1909 @default.
- NCIT_C188381 subClassOf NCIT_C2189 @default.
- NCIT_C188381 subClassOf NCIT_C274 @default.