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- NCIT_C1884 IAO_0000115 "An orally bioavailable receptor tyrosine kinase inhibitor. SU6668 binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. SU6668 also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. (NCI04)" @default.
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- NCIT_C1884 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1884 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1884 NCIT_P107 "Orantinib" @default.
- NCIT_C1884 NCIT_P108 "Orantinib" @default.
- NCIT_C1884 NCIT_P175 "702827" @default.
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- NCIT_C1884 NCIT_P325 "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called angiogenesis inhibitors." @default.
- NCIT_C1884 NCIT_P329 "38421" @default.
- NCIT_C1884 NCIT_P330 "38421" @default.
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- NCIT_C1884 NCIT_P375 "Orantinib" @default.
- NCIT_C1884 NCIT_P399 "38421" @default.
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- NCIT_C1884 normalizedInformationContent "100" @default.
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- NCIT_C1884 hasExactSynonym "3-(2,4-Dimethyl-5-((2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-1H-pyrrol-3-yl)propionic Acid" @default.
- NCIT_C1884 hasExactSynonym "ORANTINIB" @default.
- NCIT_C1884 hasExactSynonym "Orantinib" @default.
- NCIT_C1884 hasExactSynonym "Orantinibum" @default.
- NCIT_C1884 hasExactSynonym "SU 6668" @default.
- NCIT_C1884 hasExactSynonym "SU006668" @default.
- NCIT_C1884 hasExactSynonym "SU6668" @default.
- NCIT_C1884 hasExactSynonym "Sugen SU6668" @default.
- NCIT_C1884 hasExactSynonym "TSU 68" @default.
- NCIT_C1884 inSubset NCIT_C116977 @default.
- NCIT_C1884 inSubset NCIT_C116978 @default.
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- NCIT_C1884 type Class @default.
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- NCIT_C1884 label "Orantinib" @default.
- NCIT_C1884 subClassOf NCIT_C1404 @default.
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