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- NCIT_C1886 IAO_0000115 "The hydrochloride salt form of afeletecan, a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood." @default.
- NCIT_C1886 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1886 NCIT_NHC0 "C1886" @default.
- NCIT_C1886 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1886 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1886 NCIT_P108 "Afeletecan Hydrochloride" @default.
- NCIT_C1886 NCIT_P207 "C1101785" @default.
- NCIT_C1886 NCIT_P210 "215604-74-3" @default.
- NCIT_C1886 NCIT_P319 "DTJ7VPW43J" @default.
- NCIT_C1886 NCIT_P322 "FDA" @default.
- NCIT_C1886 NCIT_P322 "GDC" @default.
- NCIT_C1886 NCIT_P325 "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called camptothecins." @default.
- NCIT_C1886 NCIT_P329 "38705" @default.
- NCIT_C1886 NCIT_P330 "38705" @default.
- NCIT_C1886 NCIT_P366 "BAY_56-3722" @default.
- NCIT_C1886 NCIT_P375 "Camptothecin Glycoconjugate BAY 38-3441" @default.
- NCIT_C1886 NCIT_P399 "38705" @default.
- NCIT_C1886 normalizedInformationContent "100" @default.
- NCIT_C1886 referenceCount "1" @default.
- NCIT_C1886 hasExactSynonym "AFELETECAN HYDROCHLORIDE" @default.
- NCIT_C1886 hasExactSynonym "Afeletecan Hydrochloride" @default.
- NCIT_C1886 hasExactSynonym "BAY 38-3441" @default.
- NCIT_C1886 hasExactSynonym "BAY 56-3722" @default.
- NCIT_C1886 hasExactSynonym "BAY56-3722" @default.
- NCIT_C1886 hasExactSynonym "Camptothecin Glycoconjugate BAY 38-3441" @default.
- NCIT_C1886 inSubset NCIT_C128784 @default.
- NCIT_C1886 inSubset NCIT_C157711 @default.
- NCIT_C1886 inSubset NCIT_C157712 @default.
- NCIT_C1886 inSubset NCIT_C176424 @default.
- NCIT_C1886 inSubset NCIT_C177537 @default.
- NCIT_C1886 inSubset NCIT_C63923 @default.
- NCIT_C1886 type Class @default.
- NCIT_C1886 isDefinedBy ncit.owl @default.
- NCIT_C1886 label "Afeletecan Hydrochloride" @default.
- NCIT_C1886 subClassOf NCIT_C129824 @default.
- NCIT_C1886 subClassOf NCIT_C129825 @default.
- NCIT_C1886 subClassOf NCIT_C1748 @default.
- NCIT_C1886 subClassOf NCIT_C1886 @default.
- NCIT_C1886 subClassOf NCIT_C1904 @default.
- NCIT_C1886 subClassOf NCIT_C1908 @default.
- NCIT_C1886 subClassOf NCIT_C1909 @default.
- NCIT_C1886 subClassOf NCIT_C2189 @default.
- NCIT_C1886 subClassOf NCIT_C274 @default.
- NCIT_C1886 subClassOf NCIT_C2843 @default.
- NCIT_C1886 subClassOf NCIT_C471 @default.