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- NCIT_C188793 IAO_0000115 "A receptor-targeted oncolytic RNA virus, with potential antineoplastic and immunomodulating activities. Upon intra-tumoral administration, the oncolytic RNA virus IVX037 selectively targets specific receptors overexpressed on cancer cells, thereby allowing for selective replication in cancer cells without being able to infect and replicate in normal, healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. Following the lysis of infected cells, the replicated virus is released and can infect adjacent tumor cells, which both induces further tumor cell oncolysis and may beneficially alter the tumor microenvironment (TME). This may further activate both innate and adaptive immune responses against cancer cells." @default.
- NCIT_C188793 NCIT_NHC0 "C188793" @default.
- NCIT_C188793 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188793 NCIT_P108 "Oncolytic RNA Virus IVX037" @default.
- NCIT_C188793 NCIT_P208 "CL1794072" @default.
- NCIT_C188793 NCIT_P322 "GDC" @default.
- NCIT_C188793 NCIT_P399 "810163" @default.
- NCIT_C188793 normalizedInformationContent "100" @default.
- NCIT_C188793 referenceCount "1" @default.
- NCIT_C188793 hasExactSynonym "IVX 037" @default.
- NCIT_C188793 hasExactSynonym "IVX-037" @default.
- NCIT_C188793 hasExactSynonym "IVX037" @default.
- NCIT_C188793 hasExactSynonym "Oncolytic RNA Virus IVX037" @default.
- NCIT_C188793 hasExactSynonym "Oncolytic Virus IVX037" @default.
- NCIT_C188793 inSubset NCIT_C128784 @default.
- NCIT_C188793 inSubset NCIT_C157711 @default.
- NCIT_C188793 inSubset NCIT_C157712 @default.
- NCIT_C188793 inSubset NCIT_C176424 @default.
- NCIT_C188793 type Class @default.
- NCIT_C188793 isDefinedBy ncit.owl @default.
- NCIT_C188793 label "Oncolytic RNA Virus IVX037" @default.
- NCIT_C188793 subClassOf NCIT_C129821 @default.
- NCIT_C188793 subClassOf NCIT_C188793 @default.
- NCIT_C188793 subClassOf NCIT_C1908 @default.
- NCIT_C188793 subClassOf NCIT_C1909 @default.
- NCIT_C188793 subClassOf NCIT_C1962 @default.
- NCIT_C188793 subClassOf NCIT_C2139 @default.
- NCIT_C188793 subClassOf NCIT_C274 @default.
- NCIT_C188793 subClassOf NCIT_C307 @default.
- NCIT_C188793 subClassOf NCIT_C308 @default.
- NCIT_C188793 subClassOf NCIT_C717 @default.