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- NCIT_C188801 IAO_0000115 "A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) disialoganglioside (GD2) and CD56 (neural cell adhesion molecule 1; NCAM-1), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-GD2/anti-CD56 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in GD2- and CD56-expressing tumor cells. GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. CD56 is overexpressed on the surface of various types of cancer cells, including small cell lung cancer (SCLC) and other neuroendocrine tumors (NETs)." @default.
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- NCIT_C188801 NCIT_P108 "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C188801 NCIT_P208 "CL1794067" @default.
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- NCIT_C188801 hasExactSynonym "Anti-CD56/Anti-GD2 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C188801 hasExactSynonym "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C188801 hasExactSynonym "Anti-GD2/Anti-NCAM-1 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C188801 hasExactSynonym "Anti-GD2/CD56 Bispecific 4SCAR-expressing T-cells" @default.
- NCIT_C188801 hasExactSynonym "Bi-4SCAR GD2/CD56 T Cells" @default.
- NCIT_C188801 hasExactSynonym "GD2/CD56 Bispecific 4SCAR-T Cells" @default.
- NCIT_C188801 inSubset NCIT_C128784 @default.
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- NCIT_C188801 type Class @default.
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- NCIT_C188801 label "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells" @default.
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