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- NCIT_C188891 IAO_0000115 "An orally bioavailable third-generation inhibitor of cyclin-dependent kinase (CDK) types 2 (CDK2), 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK2/4/6 inhibitor RGT-419B selectively targets and inhibits CDK2, CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase and prevents CDK-mediated G1-S-phase transition. This leads to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation and are upregulated in many tumor cell types. In addition, RGT-419B may inhibit other kinases." @default.
- NCIT_C188891 NCIT_A7 NCIT_C17680 @default.
- NCIT_C188891 NCIT_A7 NCIT_C25842 @default.
- NCIT_C188891 NCIT_A7 NCIT_C97386 @default.
- NCIT_C188891 NCIT_NHC0 "C188891" @default.
- NCIT_C188891 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188891 NCIT_P107 "CDK2/4/6 Inhibitor RGT-419B" @default.
- NCIT_C188891 NCIT_P108 "CDK2/4/6 Inhibitor RGT-419B" @default.
- NCIT_C188891 NCIT_P208 "CL1794047" @default.
- NCIT_C188891 NCIT_P322 "CTRP" @default.
- NCIT_C188891 NCIT_P322 "GDC" @default.
- NCIT_C188891 NCIT_P399 "810499" @default.
- NCIT_C188891 normalizedInformationContent "100" @default.
- NCIT_C188891 referenceCount "1" @default.
- NCIT_C188891 hasExactSynonym "CDK2/4/6 Inhibitor RGT-419B" @default.
- NCIT_C188891 hasExactSynonym "Cyclin-dependent Kinase 2/4/6 Inhibitor RGT-419B" @default.
- NCIT_C188891 hasExactSynonym "RGT 419B" @default.
- NCIT_C188891 hasExactSynonym "RGT-419B" @default.
- NCIT_C188891 hasExactSynonym "RGT419B" @default.
- NCIT_C188891 inSubset NCIT_C116977 @default.
- NCIT_C188891 inSubset NCIT_C116978 @default.
- NCIT_C188891 inSubset NCIT_C128784 @default.
- NCIT_C188891 inSubset NCIT_C157711 @default.
- NCIT_C188891 inSubset NCIT_C157712 @default.
- NCIT_C188891 inSubset NCIT_C176424 @default.
- NCIT_C188891 type Class @default.
- NCIT_C188891 isDefinedBy ncit.owl @default.
- NCIT_C188891 label "CDK2/4/6 Inhibitor RGT-419B" @default.
- NCIT_C188891 subClassOf NCIT_C129824 @default.
- NCIT_C188891 subClassOf NCIT_C129825 @default.
- NCIT_C188891 subClassOf NCIT_C1404 @default.
- NCIT_C188891 subClassOf NCIT_C163758 @default.
- NCIT_C188891 subClassOf NCIT_C188891 @default.
- NCIT_C188891 subClassOf NCIT_C1908 @default.
- NCIT_C188891 subClassOf NCIT_C1909 @default.
- NCIT_C188891 subClassOf NCIT_C192741 @default.
- NCIT_C188891 subClassOf NCIT_C192742 @default.
- NCIT_C188891 subClassOf NCIT_C200052 @default.
- NCIT_C188891 subClassOf NCIT_C2185 @default.
- NCIT_C188891 subClassOf NCIT_C2189 @default.
- NCIT_C188891 subClassOf NCIT_C274 @default.
- NCIT_C188891 subClassOf NCIT_C471 @default.
- NCIT_C188891 subClassOf NCIT_C61074 @default.