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- NCIT_C1889 IAO_0000115 "A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents." @default.
- NCIT_C1889 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1889 NCIT_NHC0 "C1889" @default.
- NCIT_C1889 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1889 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1889 NCIT_P107 "Brostallicin" @default.
- NCIT_C1889 NCIT_P108 "Brostallicin" @default.
- NCIT_C1889 NCIT_P207 "C1122890" @default.
- NCIT_C1889 NCIT_P210 "203258-60-0" @default.
- NCIT_C1889 NCIT_P319 "RPC6R41K4I" @default.
- NCIT_C1889 NCIT_P322 "CTRP" @default.
- NCIT_C1889 NCIT_P322 "FDA" @default.
- NCIT_C1889 NCIT_P322 "GDC" @default.
- NCIT_C1889 NCIT_P329 "590644" @default.
- NCIT_C1889 NCIT_P330 "590644" @default.
- NCIT_C1889 NCIT_P350 "C30H35BrN12O5" @default.
- NCIT_C1889 NCIT_P366 "Brostallicin" @default.
- NCIT_C1889 NCIT_P375 "Brostallicin" @default.
- NCIT_C1889 NCIT_P399 "590644" @default.
- NCIT_C1889 normalizedInformationContent "100" @default.
- NCIT_C1889 referenceCount "1" @default.
- NCIT_C1889 hasExactSynonym "4-(2-Bromoacrylamido)-N'''-(2-guanidinoethyl)-1,1',1',1'''-tetramethyl-N,4':N',4':N',4'''-quater(pyrrole-2-carboxamide)" @default.
- NCIT_C1889 hasExactSynonym "BROSTALLICIN" @default.
- NCIT_C1889 hasExactSynonym "Brostallicin" @default.
- NCIT_C1889 hasExactSynonym "PNU-166196" @default.
- NCIT_C1889 inSubset NCIT_C116977 @default.
- NCIT_C1889 inSubset NCIT_C116978 @default.
- NCIT_C1889 inSubset NCIT_C128784 @default.
- NCIT_C1889 inSubset NCIT_C157711 @default.
- NCIT_C1889 inSubset NCIT_C157712 @default.
- NCIT_C1889 inSubset NCIT_C176424 @default.
- NCIT_C1889 inSubset NCIT_C177537 @default.
- NCIT_C1889 inSubset NCIT_C63923 @default.
- NCIT_C1889 type Class @default.
- NCIT_C1889 isDefinedBy ncit.owl @default.
- NCIT_C1889 label "Brostallicin" @default.
- NCIT_C1889 subClassOf NCIT_C186664 @default.
- NCIT_C1889 subClassOf NCIT_C1889 @default.
- NCIT_C1889 subClassOf NCIT_C1908 @default.
- NCIT_C1889 subClassOf NCIT_C1909 @default.
- NCIT_C1889 subClassOf NCIT_C2115 @default.
- NCIT_C1889 subClassOf NCIT_C2161 @default.
- NCIT_C1889 subClassOf NCIT_C259 @default.
- NCIT_C1889 subClassOf NCIT_C274 @default.
- NCIT_C1889 subClassOf NCIT_C2842 @default.
- NCIT_C1889 subClassOf NCIT_C446 @default.