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- NCIT_C188957 IAO_0000115 "A combination agent composed of two humanized monoclonal antibodies, PSB102, an Fc-enhanced immunoglobulin G1 (IgG1) monoclonal antibody directed against the human B-cell-specific cell surface antigen and tumor-associated antigen (TAA) CD20, and PSB107, an IgG1 monoclonal antibody directed against the TAA CD37, with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD20/CD37 monoclonal antibody combination PSB202 specifically targets and binds to CD20 and CD37 expressed on tumor cells. This induces antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against CD20- and CD37-expressing B-cells, which leads to B-cell apoptosis and the inhibition of tumor cell proliferation. CD20, a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B-cells during most stages of B-cell development, is often overexpressed in B-cell malignancies. CD37, a member of the tetraspanin superfamily of cell surface antigens, is overexpressed on a variety of cancer cell types and plays a key role in tumor cell proliferation." @default.
- NCIT_C188957 NCIT_A7 NCIT_C102769 @default.
- NCIT_C188957 NCIT_A7 NCIT_C38896 @default.
- NCIT_C188957 NCIT_NHC0 "C188957" @default.
- NCIT_C188957 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C188957 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188957 NCIT_P107 "Anti-CD20/CD37 Monoclonal Antibody Combination PSB202" @default.
- NCIT_C188957 NCIT_P108 "Anti-CD20/CD37 Monoclonal Antibody Combination PSB202" @default.
- NCIT_C188957 NCIT_P208 "CL1794000" @default.
- NCIT_C188957 NCIT_P322 "CTRP" @default.
- NCIT_C188957 NCIT_P322 "GDC" @default.
- NCIT_C188957 NCIT_P399 "810491" @default.
- NCIT_C188957 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188957 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188957 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188957 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188957 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188957 normalizedInformationContent "100" @default.
- NCIT_C188957 referenceCount "1" @default.
- NCIT_C188957 hasExactSynonym "Anti-CD20 Monoclonal Antibody/Anti-CD37 Monoclonal Antibody Combination PSB202" @default.
- NCIT_C188957 hasExactSynonym "Anti-CD20/Anti-CD37 Monoclonal Antibody Combination PSB202" @default.
- NCIT_C188957 hasExactSynonym "Anti-CD20/CD37 Monoclonal Antibody Combination PSB202" @default.
- NCIT_C188957 hasExactSynonym "PSB 202" @default.
- NCIT_C188957 hasExactSynonym "PSB-202" @default.
- NCIT_C188957 hasExactSynonym "PSB102 Plus PSB107" @default.
- NCIT_C188957 hasExactSynonym "PSB102 and PSB107" @default.
- NCIT_C188957 hasExactSynonym "PSB102/PSB107" @default.
- NCIT_C188957 hasExactSynonym "PSB202" @default.
- NCIT_C188957 inSubset NCIT_C116977 @default.
- NCIT_C188957 inSubset NCIT_C116978 @default.
- NCIT_C188957 inSubset NCIT_C128784 @default.
- NCIT_C188957 inSubset NCIT_C157711 @default.
- NCIT_C188957 inSubset NCIT_C157712 @default.
- NCIT_C188957 inSubset NCIT_C176424 @default.
- NCIT_C188957 type Class @default.
- NCIT_C188957 isDefinedBy ncit.owl @default.
- NCIT_C188957 label "Anti-CD20/CD37 Monoclonal Antibody Combination PSB202" @default.
- NCIT_C188957 subClassOf NCIT_C129821 @default.
- NCIT_C188957 subClassOf NCIT_C129822 @default.
- NCIT_C188957 subClassOf NCIT_C141215 @default.
- NCIT_C188957 subClassOf NCIT_C163758 @default.
- NCIT_C188957 subClassOf NCIT_C164034 @default.
- NCIT_C188957 subClassOf NCIT_C188957 @default.
- NCIT_C188957 subClassOf NCIT_C1908 @default.
- NCIT_C188957 subClassOf NCIT_C1909 @default.
- NCIT_C188957 subClassOf NCIT_C20401 @default.
- NCIT_C188957 subClassOf NCIT_C274 @default.
- NCIT_C188957 subClassOf NCIT_C307 @default.
- NCIT_C188957 subClassOf NCIT_C308 @default.