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- NCIT_C188959 IAO_0000115 "A trispecific immunoglobulin G (IgG)-like T-cell engaging antibody targeting the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD3/CD19/CD20 trispecific antibody 1A46 binds to CD19- and/or CD20-expressing tumor B-cell and CD3 antigen on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to CD19- and/or CD20-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse." @default.
- NCIT_C188959 NCIT_A7 NCIT_C38894 @default.
- NCIT_C188959 NCIT_A7 NCIT_C38896 @default.
- NCIT_C188959 NCIT_NHC0 "C188959" @default.
- NCIT_C188959 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C188959 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188959 NCIT_P107 "Anti-CD3/CD19/CD20 Trispecific Antibody 1A46" @default.
- NCIT_C188959 NCIT_P108 "Anti-CD3/CD19/CD20 Trispecific Antibody 1A46" @default.
- NCIT_C188959 NCIT_P208 "CL1793999" @default.
- NCIT_C188959 NCIT_P322 "CTRP" @default.
- NCIT_C188959 NCIT_P322 "GDC" @default.
- NCIT_C188959 NCIT_P399 "810492" @default.
- NCIT_C188959 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188959 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188959 NCIT_R124 NCIT_C18219 @default.
- NCIT_C188959 NCIT_R124 NCIT_C19986 @default.
- NCIT_C188959 NCIT_R124 NCIT_C40474 @default.
- NCIT_C188959 normalizedInformationContent "100" @default.
- NCIT_C188959 referenceCount "1" @default.
- NCIT_C188959 hasExactSynonym "1A46" @default.
- NCIT_C188959 hasExactSynonym "Anti-CD3/Anti-CD19/Anti-CD20 Trispecific Antibody 1A46" @default.
- NCIT_C188959 hasExactSynonym "Anti-CD3/CD19/CD20 Trispecific Antibody 1A46" @default.
- NCIT_C188959 hasExactSynonym "Anti-CD3/CD19/CD20 Trispecific Antibody CMG1A46" @default.
- NCIT_C188959 hasExactSynonym "CD19/CD20-targeting T Cell-engaging Tri-specific Antibody CMG1A46" @default.
- NCIT_C188959 hasExactSynonym "CD3/CD19/CD20 T-cell Engager CMG1A46" @default.
- NCIT_C188959 hasExactSynonym "CMG 1A46" @default.
- NCIT_C188959 hasExactSynonym "CMG-1A46" @default.
- NCIT_C188959 hasExactSynonym "CMG1A46" @default.
- NCIT_C188959 inSubset NCIT_C116977 @default.
- NCIT_C188959 inSubset NCIT_C116978 @default.
- NCIT_C188959 inSubset NCIT_C128784 @default.
- NCIT_C188959 inSubset NCIT_C157711 @default.
- NCIT_C188959 inSubset NCIT_C157712 @default.
- NCIT_C188959 inSubset NCIT_C176424 @default.
- NCIT_C188959 type Class @default.
- NCIT_C188959 isDefinedBy ncit.owl @default.
- NCIT_C188959 label "Anti-CD3/CD19/CD20 Trispecific Antibody 1A46" @default.
- NCIT_C188959 subClassOf NCIT_C112883 @default.
- NCIT_C188959 subClassOf NCIT_C112889 @default.
- NCIT_C188959 subClassOf NCIT_C129820 @default.
- NCIT_C188959 subClassOf NCIT_C129821 @default.
- NCIT_C188959 subClassOf NCIT_C129822 @default.
- NCIT_C188959 subClassOf NCIT_C141215 @default.
- NCIT_C188959 subClassOf NCIT_C163758 @default.
- NCIT_C188959 subClassOf NCIT_C164034 @default.
- NCIT_C188959 subClassOf NCIT_C188959 @default.
- NCIT_C188959 subClassOf NCIT_C1908 @default.
- NCIT_C188959 subClassOf NCIT_C1909 @default.
- NCIT_C188959 subClassOf NCIT_C198634 @default.
- NCIT_C188959 subClassOf NCIT_C20401 @default.
- NCIT_C188959 subClassOf NCIT_C274 @default.
- NCIT_C188959 subClassOf NCIT_C307 @default.
- NCIT_C188959 subClassOf NCIT_C308 @default.