Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C188961> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- NCIT_C188961 IAO_0000115 "An orally bioavailable flavored formulation composed of the hydrochloride salt form of irinotecan, a semisynthetic derivative of camptothecin, with potential antineoplastic activity. Upon oral administration of oral irinotecan HCl formulation VAL-413, irinotecan is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. In turn, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks. This results in an inhibition of DNA replication and an induction of apoptosis in cancer cells. VAL-413 may improve tolerability of oral irinotecan and improve compliance." @default.
- NCIT_C188961 NCIT_A7 NCIT_C16516 @default.
- NCIT_C188961 NCIT_NHC0 "C188961" @default.
- NCIT_C188961 NCIT_P106 "Organic Chemical" @default.
- NCIT_C188961 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C188961 NCIT_P107 "Oral Irinotecan Hydrochloride Formulation VAL-413" @default.
- NCIT_C188961 NCIT_P108 "Oral Irinotecan Hydrochloride Formulation VAL-413" @default.
- NCIT_C188961 NCIT_P208 "CL1794005" @default.
- NCIT_C188961 NCIT_P322 "CTRP" @default.
- NCIT_C188961 NCIT_P322 "GDC" @default.
- NCIT_C188961 NCIT_P399 "810504" @default.
- NCIT_C188961 NCIT_R122 NCIT_C16484 @default.
- NCIT_C188961 NCIT_R122 NCIT_C16486 @default.
- NCIT_C188961 NCIT_R122 NCIT_C16554 @default.
- NCIT_C188961 NCIT_R122 NCIT_C16865 @default.
- NCIT_C188961 NCIT_R122 NCIT_C16946 @default.
- NCIT_C188961 NCIT_R122 NCIT_C17021 @default.
- NCIT_C188961 NCIT_R122 NCIT_C17573 @default.
- NCIT_C188961 NCIT_R122 NCIT_C20027 @default.
- NCIT_C188961 NCIT_R122 NCIT_C26548 @default.
- NCIT_C188961 NCIT_R122 NCIT_C28459 @default.
- NCIT_C188961 NCIT_R122 NCIT_C45999 @default.
- NCIT_C188961 NCIT_R122 NCIT_C46000 @default.
- NCIT_C188961 NCIT_R124 NCIT_C17710 @default.
- NCIT_C188961 NCIT_R124 NCIT_C17828 @default.
- NCIT_C188961 NCIT_R124 NCIT_C28498 @default.
- NCIT_C188961 NCIT_R124 NCIT_C40576 @default.
- NCIT_C188961 NCIT_R124 NCIT_C40577 @default.
- NCIT_C188961 NCIT_R125 NCIT_C16507 @default.
- NCIT_C188961 NCIT_R125 NCIT_C16514 @default.
- NCIT_C188961 NCIT_R125 NCIT_C16956 @default.
- NCIT_C188961 NCIT_R125 NCIT_C17557 @default.
- NCIT_C188961 NCIT_R125 NCIT_C17710 @default.
- NCIT_C188961 NCIT_R125 NCIT_C17828 @default.
- NCIT_C188961 NCIT_R125 NCIT_C18264 @default.
- NCIT_C188961 NCIT_R125 NCIT_C19077 @default.
- NCIT_C188961 NCIT_R125 NCIT_C19154 @default.
- NCIT_C188961 NCIT_R125 NCIT_C20480 @default.
- NCIT_C188961 NCIT_R125 NCIT_C21049 @default.
- NCIT_C188961 NCIT_R125 NCIT_C21050 @default.
- NCIT_C188961 NCIT_R125 NCIT_C21080 @default.
- NCIT_C188961 NCIT_R125 NCIT_C25830 @default.
- NCIT_C188961 NCIT_R125 NCIT_C28498 @default.
- NCIT_C188961 NCIT_R125 NCIT_C40692 @default.
- NCIT_C188961 NCIT_R125 NCIT_C40828 @default.
- NCIT_C188961 NCIT_R125 NCIT_C41515 @default.
- NCIT_C188961 NCIT_R125 NCIT_C41543 @default.
- NCIT_C188961 NCIT_R146 NCIT_C16516 @default.
- NCIT_C188961 NCIT_R146 NCIT_C16554 @default.
- NCIT_C188961 NCIT_R146 NCIT_C16759 @default.
- NCIT_C188961 NCIT_R146 NCIT_C17021 @default.
- NCIT_C188961 NCIT_R146 NCIT_C20027 @default.
- NCIT_C188961 NCIT_R146 NCIT_C20646 @default.
- NCIT_C188961 NCIT_R146 NCIT_C26548 @default.
- NCIT_C188961 normalizedInformationContent "100" @default.
- NCIT_C188961 referenceCount "1" @default.
- NCIT_C188961 hasExactSynonym "Oral Irinotecan HCl Formulation VAL-413" @default.
- NCIT_C188961 hasExactSynonym "Oral Irinotecan Hydrochloride Formulation VAL-413" @default.
- NCIT_C188961 hasExactSynonym "Oral Irinotecan VAL-413" @default.
- NCIT_C188961 hasExactSynonym "Orotecan" @default.
- NCIT_C188961 hasExactSynonym "VAL 413" @default.
- NCIT_C188961 hasExactSynonym "VAL-413" @default.
- NCIT_C188961 hasExactSynonym "VAL413" @default.
- NCIT_C188961 inSubset NCIT_C116977 @default.
- NCIT_C188961 inSubset NCIT_C116978 @default.
- NCIT_C188961 inSubset NCIT_C128784 @default.
- NCIT_C188961 inSubset NCIT_C157711 @default.
- NCIT_C188961 inSubset NCIT_C157712 @default.
- NCIT_C188961 inSubset NCIT_C176424 @default.
- NCIT_C188961 type Class @default.
- NCIT_C188961 isDefinedBy ncit.owl @default.
- NCIT_C188961 label "Oral Irinotecan Hydrochloride Formulation VAL-413" @default.
- NCIT_C188961 subClassOf B1c309f61db3b2433f2457dbeed35f9be @default.
- NCIT_C188961 subClassOf B1d73844290804e5d65b0adbf5577206a @default.
- NCIT_C188961 subClassOf B35fcbcd5852a7f6e4bd78fc874a8e6ab @default.
- NCIT_C188961 subClassOf B378c75ec19f854271c62769cc0817d47 @default.
- NCIT_C188961 subClassOf B389eb007096de2fd0f947b1c8b4bb33c @default.
- NCIT_C188961 subClassOf B3fcfbece0e8794c67381d4f63837ac92 @default.
- NCIT_C188961 subClassOf B5374de12fa72cea9d108af387a0b9419 @default.
- NCIT_C188961 subClassOf B615b23ed5cc7bd8798cb9a6cf33beacc @default.
- NCIT_C188961 subClassOf B7eec1f5ffb68c89181ccedccd40a0492 @default.
- NCIT_C188961 subClassOf B86dd355e4362547e2006d57dd535346c @default.
- NCIT_C188961 subClassOf B8eca873be8c79a9aef345652388d8a47 @default.
- NCIT_C188961 subClassOf Bbc07cc1c7d550d24fa79fe27bb5159a2 @default.
- NCIT_C188961 subClassOf Be01397aa42fcace71aa3c94f062d5203 @default.
- NCIT_C188961 subClassOf Be893ea65bd9cb81023676b72a9ede58d @default.
- NCIT_C188961 subClassOf Beebc49cb976000304b1997e1ef7fb40e @default.
- NCIT_C188961 subClassOf Bf2b7c34b654f217b09d98c1ac7e55e9f @default.
- NCIT_C188961 subClassOf Bfa1af2c8d5a7fc45efb12d2a15cb7856 @default.
- NCIT_C188961 subClassOf Bff17f831f9be9b6d5ef8a7bff3905c3f @default.
- NCIT_C188961 subClassOf NCIT_C129824 @default.
- NCIT_C188961 subClassOf NCIT_C129825 @default.
- NCIT_C188961 subClassOf NCIT_C1748 @default.
- NCIT_C188961 subClassOf NCIT_C188961 @default.
- NCIT_C188961 subClassOf NCIT_C1904 @default.
- NCIT_C188961 subClassOf NCIT_C1908 @default.
- NCIT_C188961 subClassOf NCIT_C1909 @default.
- NCIT_C188961 subClassOf NCIT_C2189 @default.
- NCIT_C188961 subClassOf NCIT_C274 @default.
- NCIT_C188961 subClassOf NCIT_C471 @default.