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- NCIT_C189018 IAO_0000115 "A humanized monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody SPX-101 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This may kill and inhibit proliferation of CLDN18.2-expressing tumor cells. SPX-101 may trigger antibody-dependent cellular cytotoxicity (ADCC). CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C189018 NCIT_A7 NCIT_C150412 @default.
- NCIT_C189018 NCIT_NHC0 "C189018" @default.
- NCIT_C189018 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189018 NCIT_P107 "Anti-Claudin-18.2 Monoclonal Antibody SPX-101" @default.
- NCIT_C189018 NCIT_P108 "Anti-Claudin-18.2 Monoclonal Antibody SPX-101" @default.
- NCIT_C189018 NCIT_P208 "CL1793954" @default.
- NCIT_C189018 NCIT_P322 "CTRP" @default.
- NCIT_C189018 NCIT_P322 "GDC" @default.
- NCIT_C189018 NCIT_P399 "810493" @default.
- NCIT_C189018 NCIT_R124 NCIT_C17710 @default.
- NCIT_C189018 NCIT_R124 NCIT_C17828 @default.
- NCIT_C189018 NCIT_R124 NCIT_C18219 @default.
- NCIT_C189018 NCIT_R124 NCIT_C19986 @default.
- NCIT_C189018 NCIT_R124 NCIT_C40474 @default.
- NCIT_C189018 normalizedInformationContent "100" @default.
- NCIT_C189018 referenceCount "1" @default.
- NCIT_C189018 hasExactSynonym "Anti-CLDN18.2 Monoclonal Antibody SPX-101" @default.
- NCIT_C189018 hasExactSynonym "Anti-Claudin-18.2 Monoclonal Antibody SPX-101" @default.
- NCIT_C189018 hasExactSynonym "SPX 101" @default.
- NCIT_C189018 hasExactSynonym "SPX-101" @default.
- NCIT_C189018 hasExactSynonym "SPX101" @default.
- NCIT_C189018 inSubset NCIT_C116977 @default.
- NCIT_C189018 inSubset NCIT_C116978 @default.
- NCIT_C189018 inSubset NCIT_C128784 @default.
- NCIT_C189018 inSubset NCIT_C157711 @default.
- NCIT_C189018 inSubset NCIT_C157712 @default.
- NCIT_C189018 inSubset NCIT_C176424 @default.
- NCIT_C189018 type Class @default.
- NCIT_C189018 isDefinedBy ncit.owl @default.
- NCIT_C189018 label "Anti-Claudin-18.2 Monoclonal Antibody SPX-101" @default.
- NCIT_C189018 subClassOf NCIT_C129821 @default.
- NCIT_C189018 subClassOf NCIT_C129822 @default.
- NCIT_C189018 subClassOf NCIT_C163758 @default.
- NCIT_C189018 subClassOf NCIT_C179676 @default.
- NCIT_C189018 subClassOf NCIT_C189018 @default.
- NCIT_C189018 subClassOf NCIT_C1908 @default.
- NCIT_C189018 subClassOf NCIT_C1909 @default.
- NCIT_C189018 subClassOf NCIT_C200250 @default.
- NCIT_C189018 subClassOf NCIT_C20401 @default.
- NCIT_C189018 subClassOf NCIT_C274 @default.
- NCIT_C189018 subClassOf NCIT_C307 @default.
- NCIT_C189018 subClassOf NCIT_C308 @default.