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- NCIT_C189048 IAO_0000115 "An agent that targets the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and redirects T-cells to PSMA-expressing tumor cells, with potential antineoplastic activity. Although the mechanism of action has not been elucidated, upon administration, PSMA-targeting T-cell redirecting agent JNJ-80038114 targets PSMA found on PSMA-expressing tumor cells, and redirects T-cells to the PSMA-expressing tumor cells. This may result in T-cell-mediated cell death of PSMA-expressing tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors." @default.
- NCIT_C189048 NCIT_A7 NCIT_C17796 @default.
- NCIT_C189048 NCIT_NHC0 "C189048" @default.
- NCIT_C189048 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189048 NCIT_P107 "PSMA-targeting T-cell Redirecting Agent JNJ-80038114" @default.
- NCIT_C189048 NCIT_P108 "PSMA-targeting T-cell Redirecting Agent JNJ-80038114" @default.
- NCIT_C189048 NCIT_P208 "CL1794276" @default.
- NCIT_C189048 NCIT_P322 "CTRP" @default.
- NCIT_C189048 NCIT_P322 "GDC" @default.
- NCIT_C189048 NCIT_P399 "810273" @default.
- NCIT_C189048 normalizedInformationContent "100" @default.
- NCIT_C189048 referenceCount "1" @default.
- NCIT_C189048 hasExactSynonym "JNJ 80038114" @default.
- NCIT_C189048 hasExactSynonym "JNJ-80038114" @default.
- NCIT_C189048 hasExactSynonym "JNJ80038114" @default.
- NCIT_C189048 hasExactSynonym "PSMA-targeted T-cell Redirecting Agent JNJ-80038114" @default.
- NCIT_C189048 hasExactSynonym "PSMA-targeting T-cell Redirecting Agent JNJ-80038114" @default.
- NCIT_C189048 inSubset NCIT_C116977 @default.
- NCIT_C189048 inSubset NCIT_C116978 @default.
- NCIT_C189048 inSubset NCIT_C128784 @default.
- NCIT_C189048 inSubset NCIT_C157711 @default.
- NCIT_C189048 inSubset NCIT_C157712 @default.
- NCIT_C189048 inSubset NCIT_C176424 @default.
- NCIT_C189048 type Class @default.
- NCIT_C189048 isDefinedBy ncit.owl @default.
- NCIT_C189048 label "PSMA-targeting T-cell Redirecting Agent JNJ-80038114" @default.
- NCIT_C189048 subClassOf NCIT_C129820 @default.
- NCIT_C189048 subClassOf NCIT_C189048 @default.
- NCIT_C189048 subClassOf NCIT_C1908 @default.
- NCIT_C189048 subClassOf NCIT_C1909 @default.
- NCIT_C189048 subClassOf NCIT_C274 @default.
- NCIT_C189048 subClassOf NCIT_C308 @default.