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- NCIT_C189056 IAO_0000115 "A bispecific T-cell engaging antibody directed against both the tumor-associated antigen (TAA) human leukocyte antigen (HLA)-A2-restricted, melanoma-associated antigen A4 (MAGE-A4) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-HLA-A2-MAGE-A4/Anti-CD3 bispecific antibody RO7444973 simultaneously binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and HLA-A2 MAGE-A4 on MAGE-A4-expressing tumor cells. This activates and redirects CTLs to MAGE-A4-expressing tumor cells, which results in the CTL-mediated cell death of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer cell types." @default.
- NCIT_C189056 NCIT_A7 NCIT_C104515 @default.
- NCIT_C189056 NCIT_NHC0 "C189056" @default.
- NCIT_C189056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189056 NCIT_P107 "Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RO7444973" @default.
- NCIT_C189056 NCIT_P108 "Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RO7444973" @default.
- NCIT_C189056 NCIT_P208 "CL1794269" @default.
- NCIT_C189056 NCIT_P322 "CTRP" @default.
- NCIT_C189056 NCIT_P322 "GDC" @default.
- NCIT_C189056 NCIT_R124 NCIT_C17710 @default.
- NCIT_C189056 NCIT_R124 NCIT_C17828 @default.
- NCIT_C189056 NCIT_R124 NCIT_C18219 @default.
- NCIT_C189056 NCIT_R124 NCIT_C19986 @default.
- NCIT_C189056 NCIT_R124 NCIT_C40474 @default.
- NCIT_C189056 normalizedInformationContent "100" @default.
- NCIT_C189056 referenceCount "1" @default.
- NCIT_C189056 hasExactSynonym "Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RG6129" @default.
- NCIT_C189056 hasExactSynonym "Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RO7444973" @default.
- NCIT_C189056 hasExactSynonym "Anti-HLA-A2-MAGE-A4/CD3 Bispecific Antibody RO7444973" @default.
- NCIT_C189056 hasExactSynonym "HLA-A2-MAGE-A4 x CD3 Bispecific Antibody RO7444973" @default.
- NCIT_C189056 hasExactSynonym "RG 6129" @default.
- NCIT_C189056 hasExactSynonym "RG-6129" @default.
- NCIT_C189056 hasExactSynonym "RG6129" @default.
- NCIT_C189056 hasExactSynonym "RO 7444973" @default.
- NCIT_C189056 hasExactSynonym "RO-7444973" @default.
- NCIT_C189056 hasExactSynonym "RO7444973" @default.
- NCIT_C189056 inSubset NCIT_C116977 @default.
- NCIT_C189056 inSubset NCIT_C116978 @default.
- NCIT_C189056 inSubset NCIT_C128784 @default.
- NCIT_C189056 inSubset NCIT_C157711 @default.
- NCIT_C189056 inSubset NCIT_C157712 @default.
- NCIT_C189056 inSubset NCIT_C176424 @default.
- NCIT_C189056 type Class @default.
- NCIT_C189056 isDefinedBy ncit.owl @default.
- NCIT_C189056 label "Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RO7444973" @default.
- NCIT_C189056 subClassOf NCIT_C112883 @default.
- NCIT_C189056 subClassOf NCIT_C129821 @default.
- NCIT_C189056 subClassOf NCIT_C129822 @default.
- NCIT_C189056 subClassOf NCIT_C1454 @default.
- NCIT_C189056 subClassOf NCIT_C189056 @default.
- NCIT_C189056 subClassOf NCIT_C1908 @default.
- NCIT_C189056 subClassOf NCIT_C1909 @default.
- NCIT_C189056 subClassOf NCIT_C201282 @default.
- NCIT_C189056 subClassOf NCIT_C20401 @default.
- NCIT_C189056 subClassOf NCIT_C274 @default.
- NCIT_C189056 subClassOf NCIT_C28227 @default.
- NCIT_C189056 subClassOf NCIT_C307 @default.
- NCIT_C189056 subClassOf NCIT_C308 @default.