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- NCIT_C189058 IAO_0000115 "A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) CD19 and CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/anti-CD70 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in CD19- and CD70-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance. CD19 and CD70 are expressed at high levels on tumor cells but not at significant levels on normal tissues. Targeting two antigens may protect against antigen escape and may enhance CAR-T cell efficacy." @default.
- NCIT_C189058 NCIT_A7 NCIT_C104079 @default.
- NCIT_C189058 NCIT_A7 NCIT_C38894 @default.
- NCIT_C189058 NCIT_NHC0 "C189058" @default.
- NCIT_C189058 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189058 NCIT_P108 "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C189058 NCIT_P208 "CL1794268" @default.
- NCIT_C189058 NCIT_P399 "810251" @default.
- NCIT_C189058 normalizedInformationContent "100" @default.
- NCIT_C189058 referenceCount "1" @default.
- NCIT_C189058 hasExactSynonym "Anti-CD19/Anti-CD70 4SCAR T-cells" @default.
- NCIT_C189058 hasExactSynonym "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C189058 hasExactSynonym "Anti-CD19/CD70 Bispecific 4SCAR T-cells" @default.
- NCIT_C189058 hasExactSynonym "Bi-4SCAR CD19/70 T-cells" @default.
- NCIT_C189058 hasExactSynonym "Bi-specific CD19/70 4SCAR-T Cells" @default.
- NCIT_C189058 hasExactSynonym "CD19/70 Bi-specific 4SCAR-T Cells" @default.
- NCIT_C189058 inSubset NCIT_C128784 @default.
- NCIT_C189058 inSubset NCIT_C176424 @default.
- NCIT_C189058 type Class @default.
- NCIT_C189058 isDefinedBy ncit.owl @default.
- NCIT_C189058 label "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C189058 subClassOf NCIT_C129820 @default.
- NCIT_C189058 subClassOf NCIT_C129821 @default.
- NCIT_C189058 subClassOf NCIT_C129826 @default.
- NCIT_C189058 subClassOf NCIT_C137999 @default.
- NCIT_C189058 subClassOf NCIT_C142078 @default.
- NCIT_C189058 subClassOf NCIT_C154231 @default.
- NCIT_C189058 subClassOf NCIT_C176018 @default.
- NCIT_C189058 subClassOf NCIT_C189058 @default.
- NCIT_C189058 subClassOf NCIT_C1908 @default.
- NCIT_C189058 subClassOf NCIT_C1909 @default.
- NCIT_C189058 subClassOf NCIT_C1962 @default.
- NCIT_C189058 subClassOf NCIT_C201176 @default.
- NCIT_C189058 subClassOf NCIT_C274 @default.
- NCIT_C189058 subClassOf NCIT_C307 @default.
- NCIT_C189058 subClassOf NCIT_C308 @default.