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- NCIT_C189059 IAO_0000115 "A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) CD19 and B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific glycoprotein B29), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/anti-CD79b 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in CD19- and CD79b-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD79b, a B cell surface antigen and critical receptor for successful B cell development, is part of the B cell receptor (BCR) signaling complex. It is widely expressed in certain subtypes of B cell lymphomas. CD19 and CD79b are expressed at high levels on tumor cells but not at significant levels on normal tissues. Targeting two antigens may protect against antigen escape and may enhance CAR-T cell efficacy." @default.
- NCIT_C189059 NCIT_A7 NCIT_C38894 @default.
- NCIT_C189059 NCIT_A7 NCIT_C97426 @default.
- NCIT_C189059 NCIT_NHC0 "C189059" @default.
- NCIT_C189059 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189059 NCIT_P108 "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C189059 NCIT_P208 "CL1794267" @default.
- NCIT_C189059 NCIT_P399 "810252" @default.
- NCIT_C189059 normalizedInformationContent "100" @default.
- NCIT_C189059 referenceCount "1" @default.
- NCIT_C189059 hasExactSynonym "Anti-CD19/Anti-CD79b 4SCAR T-cells" @default.
- NCIT_C189059 hasExactSynonym "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C189059 hasExactSynonym "Anti-CD19/CD79b Bispecific 4SCAR T-cells" @default.
- NCIT_C189059 hasExactSynonym "Bi-4SCAR-CD19/79b T-cells" @default.
- NCIT_C189059 hasExactSynonym "Bi-specific CD19/79b 4SCAR-T Cells" @default.
- NCIT_C189059 hasExactSynonym "CD19/79b Bi-specific 4SCAR-T Cells" @default.
- NCIT_C189059 inSubset NCIT_C128784 @default.
- NCIT_C189059 inSubset NCIT_C176424 @default.
- NCIT_C189059 type Class @default.
- NCIT_C189059 isDefinedBy ncit.owl @default.
- NCIT_C189059 label "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells" @default.
- NCIT_C189059 subClassOf NCIT_C129820 @default.
- NCIT_C189059 subClassOf NCIT_C129821 @default.
- NCIT_C189059 subClassOf NCIT_C129826 @default.
- NCIT_C189059 subClassOf NCIT_C137999 @default.
- NCIT_C189059 subClassOf NCIT_C142078 @default.
- NCIT_C189059 subClassOf NCIT_C154231 @default.
- NCIT_C189059 subClassOf NCIT_C176018 @default.
- NCIT_C189059 subClassOf NCIT_C189059 @default.
- NCIT_C189059 subClassOf NCIT_C1908 @default.
- NCIT_C189059 subClassOf NCIT_C1909 @default.
- NCIT_C189059 subClassOf NCIT_C1962 @default.
- NCIT_C189059 subClassOf NCIT_C274 @default.
- NCIT_C189059 subClassOf NCIT_C307 @default.
- NCIT_C189059 subClassOf NCIT_C308 @default.