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- NCIT_C189061 IAO_0000115 "A monospecific hexamer-forming antibody, based on the HexaBody technology platform, directed against the cell surface antigen CD27, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD27 monoclonal antibody GEN1053/BNT313 targets and binds to CD27 expressed on a variety of immune cell types, including most T-lymphocytes, and forming a hexamer upon binding. This induces CD27-mediated signaling, and enhances CD27-mediated responses, including the expansion of antigen-activated T-cells and natural killer (NK) cells. This restores immune function and leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD27, a co-stimulatory molecule and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes, memory B-cells and NK cells. It plays an important role in NK cell-mediated cytolytic activity and T- and B-lymphocyte proliferation and activation." @default.
- NCIT_C189061 NCIT_A7 NCIT_C104073 @default.
- NCIT_C189061 NCIT_NHC0 "C189061" @default.
- NCIT_C189061 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C189061 NCIT_P107 "Anti-CD27 Monoclonal Antibody GEN1053/BNT313" @default.
- NCIT_C189061 NCIT_P108 "Anti-CD27 Monoclonal Antibody GEN1053/BNT313" @default.
- NCIT_C189061 NCIT_P208 "CL1794261" @default.
- NCIT_C189061 NCIT_P322 "GDC" @default.
- NCIT_C189061 NCIT_P399 "810257" @default.
- NCIT_C189061 NCIT_R124 NCIT_C17710 @default.
- NCIT_C189061 NCIT_R124 NCIT_C17828 @default.
- NCIT_C189061 NCIT_R124 NCIT_C18219 @default.
- NCIT_C189061 NCIT_R124 NCIT_C19986 @default.
- NCIT_C189061 NCIT_R124 NCIT_C40474 @default.
- NCIT_C189061 normalizedInformationContent "100" @default.
- NCIT_C189061 referenceCount "1" @default.
- NCIT_C189061 hasExactSynonym "Anti-CD27 Monoclonal Antibody GEN1053/BNT313" @default.
- NCIT_C189061 hasExactSynonym "BNT 313" @default.
- NCIT_C189061 hasExactSynonym "BNT-313" @default.
- NCIT_C189061 hasExactSynonym "BNT313" @default.
- NCIT_C189061 hasExactSynonym "GEN 1053" @default.
- NCIT_C189061 hasExactSynonym "GEN-1053" @default.
- NCIT_C189061 hasExactSynonym "GEN1053" @default.
- NCIT_C189061 hasExactSynonym "GEN1053/BNT313" @default.
- NCIT_C189061 inSubset NCIT_C116977 @default.
- NCIT_C189061 inSubset NCIT_C116978 @default.
- NCIT_C189061 inSubset NCIT_C128784 @default.
- NCIT_C189061 inSubset NCIT_C157711 @default.
- NCIT_C189061 inSubset NCIT_C157712 @default.
- NCIT_C189061 inSubset NCIT_C176424 @default.
- NCIT_C189061 type Class @default.
- NCIT_C189061 isDefinedBy ncit.owl @default.
- NCIT_C189061 label "Anti-CD27 Monoclonal Antibody GEN1053/BNT313" @default.
- NCIT_C189061 subClassOf NCIT_C129821 @default.
- NCIT_C189061 subClassOf NCIT_C129822 @default.
- NCIT_C189061 subClassOf NCIT_C163758 @default.
- NCIT_C189061 subClassOf NCIT_C189061 @default.
- NCIT_C189061 subClassOf NCIT_C1908 @default.
- NCIT_C189061 subClassOf NCIT_C1909 @default.
- NCIT_C189061 subClassOf NCIT_C192186 @default.
- NCIT_C189061 subClassOf NCIT_C201118 @default.
- NCIT_C189061 subClassOf NCIT_C20401 @default.
- NCIT_C189061 subClassOf NCIT_C274 @default.
- NCIT_C189061 subClassOf NCIT_C307 @default.
- NCIT_C189061 subClassOf NCIT_C308 @default.